Facial soft tissue augmentation using autologous fat mixed with stromal vascular fraction

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background Autologous fat grafting evolved over the twentieth century to become a quick, safe, and reliable method for restoring volume. However, autologous fat grafts have some problems including uncertain viability of the grafted fat and a low rate of graft survival. To overcome the problems associated with autologous fat grafts, we used uncultured adipose tissue-derived stromal cell (stromal vascular fraction, SVF) assisted autologous fat grafting. Thus, the purpose of this study was to evaluate the effect of SVF in a clinical trial. Methods SVF cells were freshly isolated from half of the aspirated fat and were used in combination with the other half of the aspirated fat during the procedure. Between March 2007 and February 2008, a total of 9 SVF-assisted fat grafts were performed in 9 patients. The patients were followed for 12 weeks after treatment. Data collected at each follow-up visit included clinical examination of the graft site(s), photographs for historical comparison, and information from a patient questionnaire that measured the outcomes from the patient perspective. The photographs were evaluated by medical professionals. Results Scores of the left facial area grafted with adipose tissue mixed with SVF cells were significantly higher compared with those of the right facial area grafted with adipose tissue without SVF cells. There was no significant adverse effect. Conclusions The subjective patient satisfaction survey and surgeon survey showed that SVFassisted fat grafting was a surgical procedure with superior results.

Original languageEnglish
Pages (from-to)534-539
Number of pages6
JournalArchives of Plastic Surgery
Volume39
Issue number5
DOIs
Publication statusPublished - 2012 Sep 1

Fingerprint

Blood Vessels
Fats
Transplants
Adipose Tissue
Graft Survival
Stromal Cells
Patient Satisfaction
Clinical Trials
Surveys and Questionnaires

Keywords

  • Adipose tissue
  • Cell transplants
  • Mesenchymal stem cells
  • Tissue grafts

ASJC Scopus subject areas

  • Surgery

Cite this

@article{5f7e983b0b7248468214e23faac55270,
title = "Facial soft tissue augmentation using autologous fat mixed with stromal vascular fraction",
abstract = "Background Autologous fat grafting evolved over the twentieth century to become a quick, safe, and reliable method for restoring volume. However, autologous fat grafts have some problems including uncertain viability of the grafted fat and a low rate of graft survival. To overcome the problems associated with autologous fat grafts, we used uncultured adipose tissue-derived stromal cell (stromal vascular fraction, SVF) assisted autologous fat grafting. Thus, the purpose of this study was to evaluate the effect of SVF in a clinical trial. Methods SVF cells were freshly isolated from half of the aspirated fat and were used in combination with the other half of the aspirated fat during the procedure. Between March 2007 and February 2008, a total of 9 SVF-assisted fat grafts were performed in 9 patients. The patients were followed for 12 weeks after treatment. Data collected at each follow-up visit included clinical examination of the graft site(s), photographs for historical comparison, and information from a patient questionnaire that measured the outcomes from the patient perspective. The photographs were evaluated by medical professionals. Results Scores of the left facial area grafted with adipose tissue mixed with SVF cells were significantly higher compared with those of the right facial area grafted with adipose tissue without SVF cells. There was no significant adverse effect. Conclusions The subjective patient satisfaction survey and surgeon survey showed that SVFassisted fat grafting was a surgical procedure with superior results.",
keywords = "Adipose tissue, Cell transplants, Mesenchymal stem cells, Tissue grafts",
author = "Lee, {Sang Kyun} and Deok-Woo Kim and Eun-Sang Dhong and Park, {Seung Ha} and Yoon, {Eul Sik}",
year = "2012",
month = "9",
day = "1",
doi = "10.5999/aps.2012.39.5.534",
language = "English",
volume = "39",
pages = "534--539",
journal = "Archives of Plastic Surgery",
issn = "2234-6163",
publisher = "Korean Society of Plastic and Reconstructive Surgeons",
number = "5",

}

TY - JOUR

T1 - Facial soft tissue augmentation using autologous fat mixed with stromal vascular fraction

AU - Lee, Sang Kyun

AU - Kim, Deok-Woo

AU - Dhong, Eun-Sang

AU - Park, Seung Ha

AU - Yoon, Eul Sik

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background Autologous fat grafting evolved over the twentieth century to become a quick, safe, and reliable method for restoring volume. However, autologous fat grafts have some problems including uncertain viability of the grafted fat and a low rate of graft survival. To overcome the problems associated with autologous fat grafts, we used uncultured adipose tissue-derived stromal cell (stromal vascular fraction, SVF) assisted autologous fat grafting. Thus, the purpose of this study was to evaluate the effect of SVF in a clinical trial. Methods SVF cells were freshly isolated from half of the aspirated fat and were used in combination with the other half of the aspirated fat during the procedure. Between March 2007 and February 2008, a total of 9 SVF-assisted fat grafts were performed in 9 patients. The patients were followed for 12 weeks after treatment. Data collected at each follow-up visit included clinical examination of the graft site(s), photographs for historical comparison, and information from a patient questionnaire that measured the outcomes from the patient perspective. The photographs were evaluated by medical professionals. Results Scores of the left facial area grafted with adipose tissue mixed with SVF cells were significantly higher compared with those of the right facial area grafted with adipose tissue without SVF cells. There was no significant adverse effect. Conclusions The subjective patient satisfaction survey and surgeon survey showed that SVFassisted fat grafting was a surgical procedure with superior results.

AB - Background Autologous fat grafting evolved over the twentieth century to become a quick, safe, and reliable method for restoring volume. However, autologous fat grafts have some problems including uncertain viability of the grafted fat and a low rate of graft survival. To overcome the problems associated with autologous fat grafts, we used uncultured adipose tissue-derived stromal cell (stromal vascular fraction, SVF) assisted autologous fat grafting. Thus, the purpose of this study was to evaluate the effect of SVF in a clinical trial. Methods SVF cells were freshly isolated from half of the aspirated fat and were used in combination with the other half of the aspirated fat during the procedure. Between March 2007 and February 2008, a total of 9 SVF-assisted fat grafts were performed in 9 patients. The patients were followed for 12 weeks after treatment. Data collected at each follow-up visit included clinical examination of the graft site(s), photographs for historical comparison, and information from a patient questionnaire that measured the outcomes from the patient perspective. The photographs were evaluated by medical professionals. Results Scores of the left facial area grafted with adipose tissue mixed with SVF cells were significantly higher compared with those of the right facial area grafted with adipose tissue without SVF cells. There was no significant adverse effect. Conclusions The subjective patient satisfaction survey and surgeon survey showed that SVFassisted fat grafting was a surgical procedure with superior results.

KW - Adipose tissue

KW - Cell transplants

KW - Mesenchymal stem cells

KW - Tissue grafts

UR - http://www.scopus.com/inward/record.url?scp=84866483062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866483062&partnerID=8YFLogxK

U2 - 10.5999/aps.2012.39.5.534

DO - 10.5999/aps.2012.39.5.534

M3 - Article

VL - 39

SP - 534

EP - 539

JO - Archives of Plastic Surgery

JF - Archives of Plastic Surgery

SN - 2234-6163

IS - 5

ER -