Facile esterification of alcohols with 2-Acyl-4,5-dichloropyridazin-3(2 H)-ones under Friedel-Crafts conditions

Bo Ram Kim, Gi Hyeon Sung, Ki Eun Ryu, Hyo Jae Yoon, Sang Gyeong Lee, Yong Jin Yoon

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Abstract

This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel-Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel-Crafts conditions, representing a rapid, practical, and efficient method of esterification.

Original languageEnglish
Article numberst-2014-u0361-l
Pages (from-to)1909-1915
Number of pages7
JournalSynlett
Volume25
Issue number13
DOIs
Publication statusPublished - 2014 Jan 1

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Esterification
Alcohols
Esters
Atoms
Economics
Temperature

ASJC Scopus subject areas

  • Organic Chemistry

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Kim, B. R., Sung, G. H., Ryu, K. E., Yoon, H. J., Lee, S. G., & Yoon, Y. J. (2014). Facile esterification of alcohols with 2-Acyl-4,5-dichloropyridazin-3(2 H)-ones under Friedel-Crafts conditions. Synlett, 25(13), 1909-1915. [st-2014-u0361-l]. https://doi.org/10.1055/s-0034-1378335

Facile esterification of alcohols with 2-Acyl-4,5-dichloropyridazin-3(2 H)-ones under Friedel-Crafts conditions. / Kim, Bo Ram; Sung, Gi Hyeon; Ryu, Ki Eun; Yoon, Hyo Jae; Lee, Sang Gyeong; Yoon, Yong Jin.

In: Synlett, Vol. 25, No. 13, st-2014-u0361-l, 01.01.2014, p. 1909-1915.

Research output: Contribution to journalArticle

Kim, Bo Ram ; Sung, Gi Hyeon ; Ryu, Ki Eun ; Yoon, Hyo Jae ; Lee, Sang Gyeong ; Yoon, Yong Jin. / Facile esterification of alcohols with 2-Acyl-4,5-dichloropyridazin-3(2 H)-ones under Friedel-Crafts conditions. In: Synlett. 2014 ; Vol. 25, No. 13. pp. 1909-1915.
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