Facile esterification of alcohols with 2-Acyl-4,5-dichloropyridazin-3(2 H)-ones under Friedel-Crafts conditions

Bo Ram Kim, Gi Hyeon Sung, Ki Eun Ryu, Hyo Jae Yoon, Sang Gyeong Lee, Yong Jin Yoon

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel-Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel-Crafts conditions, representing a rapid, practical, and efficient method of esterification.

Original languageEnglish
Article numberst-2014-u0361-l
Pages (from-to)1909-1915
Number of pages7
JournalSynlett
Volume25
Issue number13
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Organic Chemistry

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