Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du, Xiaofeng Chen, Young-Hag Koh, Bo Lei

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalMaterials Letters
Volume122
DOIs
Publication statusPublished - 2014 May 1

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Keywords

  • Biomaterials
  • Hierarchical pores
  • Nanofibrous scaffolds
  • Phase separation
  • Porous materials

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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