Factors Associated with Antidepressant Dosing in Asia: Findings from the Research on Asian Psychotropic Prescription Study

Kamini Rajaratnam, Yu Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian Mei Si, Kok Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan Ling He, Min-Soo Lee, Shu Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J. Tanra, Margarita Maramis, Winston Wu Dien Shen, Norman SartoriusEe Heok Kua, Chay Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J. Baldessarini, Kang Sim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120-129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume36
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

Keywords

  • antidepressant
  • bipolar
  • depression
  • doses
  • mood stabilizer

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Rajaratnam, K., Xiang, Y. T., Tripathi, A., Chiu, H. F. K., Si, T. M., Chee, K. Y., Avasthi, A., Grover, S., Chong, M. Y., Kuga, H., Kanba, S., He, Y. L., Lee, M-S., Yang, S. Y., Udomratn, P., Kallivayalil, R. A., Tanra, A. J., Maramis, M., Shen, W. W. D., ... Sim, K. (2016). Factors Associated with Antidepressant Dosing in Asia: Findings from the Research on Asian Psychotropic Prescription Study. Journal of Clinical Psychopharmacology, 36(6), 716-719. https://doi.org/10.1097/JCP.0000000000000591