Factors associated with exacerbation in mild-to-moderate COPD patients

Joo Kyung Kim, Soo Haeng Lee, Bho Hyeon Lee, Chang Youl Lee, Do Jin Kim, Kyung-Hoon Min, Sung Kyoun Kim, Kwang Ha Yoo, Ki Suck Jung, Yong Il Hwang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: COPD exacerbation negatively impacts the patient’s quality of life and lung function, increases mortality, and increases socioeconomic costs. In a real-world setting, the majority of patients with COPD have mild-to-moderate airflow limitation. Therefore, it is important to evaluate COPD exacerbation in patients with mild-to-moderate airflow limitation, although most studies have focused on the patients with moderate or severe COPD. The objective of this study was to evaluate factors associated with COPD exacerbation in patients with mild-to-moderate airflow limitation. Methods: Patients registered in the Korean COPD Subtype Study cohort were recruited from 37 tertiary referral hospitals in Korea. We obtained their clinical data including demographic characteristics, past medical history, and comorbidities from medical records. Patients were required to visit the hospital to document their COPD status using self-administered questionnaires every 6 months. Results: A total of 570 patients with mild-to-moderate airflow limitation were enrolled. During the first year of follow-up, 30.5% patients experienced acute exacerbation, with exacerbations being more common in patients with poor lung function. Assessed factors associated with COPD exacerbation included COPD assessment test scores, modified Medical Research Council dyspnea assessment test scores, St George’s Respiratory Questionnaire for COPD scores, a previous history of exacerbation, and histories of pneumonia and allergic rhinitis. Logistic regression tests revealed St George’s Respiratory Questionnaire for COPD scores (odds ratio [OR], 1.02; 95% confidence interval [CI], 1.00-1.04; P=0.034), a previous history of exacerbation (OR, 3.12; 95% CI, 1.35-7.23; P=0.008), and a history of pneumonia (OR, 1.85; 95% CI, 1.06-3.25; P=0.032) as risk factors for COPD exacerbation. Conclusion: Our results suggest that COPD exacerbation in patients with mild-to-moderate airflow limitation is associated with the patient’s quality of life, previous history of exacerbation, and history of pneumonia.

Original languageEnglish
Pages (from-to)1327-1333
Number of pages7
JournalInternational Journal of COPD
Volume11
Issue number1
DOIs
Publication statusPublished - 2016 Jun 16

Fingerprint

Chronic Obstructive Pulmonary Disease
Pneumonia
Odds Ratio
Confidence Intervals
Quality of Life
Lung
Korea
Tertiary Care Centers
Dyspnea
Medical Records
Biomedical Research
Comorbidity
Cohort Studies
Logistic Models
Demography
Costs and Cost Analysis

Keywords

  • COPD
  • Exacerbation
  • Risk factors

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Kim, J. K., Lee, S. H., Lee, B. H., Lee, C. Y., Kim, D. J., Min, K-H., ... Hwang, Y. I. (2016). Factors associated with exacerbation in mild-to-moderate COPD patients. International Journal of COPD, 11(1), 1327-1333. https://doi.org/10.2147/COPD.S105583

Factors associated with exacerbation in mild-to-moderate COPD patients. / Kim, Joo Kyung; Lee, Soo Haeng; Lee, Bho Hyeon; Lee, Chang Youl; Kim, Do Jin; Min, Kyung-Hoon; Kim, Sung Kyoun; Yoo, Kwang Ha; Jung, Ki Suck; Hwang, Yong Il.

In: International Journal of COPD, Vol. 11, No. 1, 16.06.2016, p. 1327-1333.

Research output: Contribution to journalArticle

Kim, JK, Lee, SH, Lee, BH, Lee, CY, Kim, DJ, Min, K-H, Kim, SK, Yoo, KH, Jung, KS & Hwang, YI 2016, 'Factors associated with exacerbation in mild-to-moderate COPD patients', International Journal of COPD, vol. 11, no. 1, pp. 1327-1333. https://doi.org/10.2147/COPD.S105583
Kim, Joo Kyung ; Lee, Soo Haeng ; Lee, Bho Hyeon ; Lee, Chang Youl ; Kim, Do Jin ; Min, Kyung-Hoon ; Kim, Sung Kyoun ; Yoo, Kwang Ha ; Jung, Ki Suck ; Hwang, Yong Il. / Factors associated with exacerbation in mild-to-moderate COPD patients. In: International Journal of COPD. 2016 ; Vol. 11, No. 1. pp. 1327-1333.
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AU - Min, Kyung-Hoon

AU - Kim, Sung Kyoun

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