Factors associated with quality of life and functional disability among rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs for at least 6 months

Sang Cheol Bae, Soo Kyung Cho, Soyoung Won, Hye Soon Lee, Sang Heon Lee, Young Mo Kang, Sang Hoon Lee, Yeon Ah Lee, Jung Yoon Choe, Won Tae Chung, Chang Hee Suh, Seung Cheol Shim, Jisoo Lee, Bo Young Yoon, Dong Wook Kim, Shin Seok Lee, Wan Hee Yoo, Jin Seok Kim, Young Ok Jung, Seong Su NahChoong Ki Lee, Gwan Gyu Song, Sungjae Choi, Chung Il Joung, Hyein Koh, Young Joo Kim

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Abstract

Aim: To determine characteristics of rheumatoid arthritis (RA) patients in Korea using disease-modifying anti-rheumatic drugs (DMARDs) for at least 6 months, and to identify factors associated with poor health-related outcomes. Method: A total of 2000 RA patients aged > 20 years, treated with DMARDs for at least 6 months, and signed informed consent, were enrolled in this non-interventional, multicenter, cross-sectional observational study from December 2012 to June 2013. Health-related quality of life (HRQoL) was measured using EuroQuol 5D (EQ-5D) and functional disability was measured using the Korean Health Assessment Questionnaire (KHAQ). Univariate and multivariate linear regression analyses were used to determine the association between patient characteristics and patient-reported outcomes (PROs). Results: Of all RA patients, 84% were female, patients with low Disease Activity Score of 28 joints erythrocyte sedimentation rate (DAS-28-ESR < 3.2) was 54%, while moderate (DAS-28-ESR 3.2-5.1) and high disease activity score (DAS-28-ESR > 5.1) were 38% and 7.6%, respectively. Mean EQ-5D index score and KHAQ score were 0.6 ± 0.28 and 0.7 ± 0.67, respectively. In multivariate analysis with both PROs, average HRQoL and functional disability score appeared to be worse in persons with older age compared to younger age (P < 0.001), and worse in females compared to males (P < 0.001). Compared to patients having lower DAS (< 3.2), those with moderate and highest DAS (3.2-5.1 and > 5.1) had worse outcome measures (P < 0.001). Conclusion: In this study, higher DAS was one of the most influential factors for poor PROs among all other factors. Therefore, we could suggest appropriate treatment approaches according to DAS along with other significantly associated factors with PROs in the early stage of RA.

Original languageEnglish
JournalInternational Journal of Rheumatic Diseases
DOIs
Publication statusAccepted/In press - 2016 Jan 1

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amsonic acid
Antirheumatic Agents
Rheumatoid Arthritis
Quality of Life
Health
Blood Sedimentation
Korea
Informed Consent
Observational Studies
Linear Models
Multivariate Analysis
Cross-Sectional Studies
Joints
Regression Analysis
Outcome Assessment (Health Care)
Patient Reported Outcome Measures

Keywords

  • Disease Activity Score
  • EuroQol EQ-5D
  • Korean Health Assessment Questionnaire
  • Patient-reported outcomes
  • Quality of life
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Factors associated with quality of life and functional disability among rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs for at least 6 months. / Bae, Sang Cheol; Cho, Soo Kyung; Won, Soyoung; Lee, Hye Soon; Lee, Sang Heon; Kang, Young Mo; Lee, Sang Hoon; Lee, Yeon Ah; Choe, Jung Yoon; Chung, Won Tae; Suh, Chang Hee; Shim, Seung Cheol; Lee, Jisoo; Yoon, Bo Young; Kim, Dong Wook; Lee, Shin Seok; Yoo, Wan Hee; Kim, Jin Seok; Jung, Young Ok; Nah, Seong Su; Lee, Choong Ki; Song, Gwan Gyu; Choi, Sungjae; Joung, Chung Il; Koh, Hyein; Kim, Young Joo.

In: International Journal of Rheumatic Diseases, 01.01.2016.

Research output: Contribution to journalArticle

Bae, SC, Cho, SK, Won, S, Lee, HS, Lee, SH, Kang, YM, Lee, SH, Lee, YA, Choe, JY, Chung, WT, Suh, CH, Shim, SC, Lee, J, Yoon, BY, Kim, DW, Lee, SS, Yoo, WH, Kim, JS, Jung, YO, Nah, SS, Lee, CK, Song, GG, Choi, S, Joung, CI, Koh, H & Kim, YJ 2016, 'Factors associated with quality of life and functional disability among rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs for at least 6 months', International Journal of Rheumatic Diseases. https://doi.org/10.1111/1756-185X.12915
Bae, Sang Cheol ; Cho, Soo Kyung ; Won, Soyoung ; Lee, Hye Soon ; Lee, Sang Heon ; Kang, Young Mo ; Lee, Sang Hoon ; Lee, Yeon Ah ; Choe, Jung Yoon ; Chung, Won Tae ; Suh, Chang Hee ; Shim, Seung Cheol ; Lee, Jisoo ; Yoon, Bo Young ; Kim, Dong Wook ; Lee, Shin Seok ; Yoo, Wan Hee ; Kim, Jin Seok ; Jung, Young Ok ; Nah, Seong Su ; Lee, Choong Ki ; Song, Gwan Gyu ; Choi, Sungjae ; Joung, Chung Il ; Koh, Hyein ; Kim, Young Joo. / Factors associated with quality of life and functional disability among rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs for at least 6 months. In: International Journal of Rheumatic Diseases. 2016.
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abstract = "Aim: To determine characteristics of rheumatoid arthritis (RA) patients in Korea using disease-modifying anti-rheumatic drugs (DMARDs) for at least 6 months, and to identify factors associated with poor health-related outcomes. Method: A total of 2000 RA patients aged > 20 years, treated with DMARDs for at least 6 months, and signed informed consent, were enrolled in this non-interventional, multicenter, cross-sectional observational study from December 2012 to June 2013. Health-related quality of life (HRQoL) was measured using EuroQuol 5D (EQ-5D) and functional disability was measured using the Korean Health Assessment Questionnaire (KHAQ). Univariate and multivariate linear regression analyses were used to determine the association between patient characteristics and patient-reported outcomes (PROs). Results: Of all RA patients, 84{\%} were female, patients with low Disease Activity Score of 28 joints erythrocyte sedimentation rate (DAS-28-ESR < 3.2) was 54{\%}, while moderate (DAS-28-ESR 3.2-5.1) and high disease activity score (DAS-28-ESR > 5.1) were 38{\%} and 7.6{\%}, respectively. Mean EQ-5D index score and KHAQ score were 0.6 ± 0.28 and 0.7 ± 0.67, respectively. In multivariate analysis with both PROs, average HRQoL and functional disability score appeared to be worse in persons with older age compared to younger age (P < 0.001), and worse in females compared to males (P < 0.001). Compared to patients having lower DAS (< 3.2), those with moderate and highest DAS (3.2-5.1 and > 5.1) had worse outcome measures (P < 0.001). Conclusion: In this study, higher DAS was one of the most influential factors for poor PROs among all other factors. Therefore, we could suggest appropriate treatment approaches according to DAS along with other significantly associated factors with PROs in the early stage of RA.",
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T1 - Factors associated with quality of life and functional disability among rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs for at least 6 months

AU - Bae, Sang Cheol

AU - Cho, Soo Kyung

AU - Won, Soyoung

AU - Lee, Hye Soon

AU - Lee, Sang Heon

AU - Kang, Young Mo

AU - Lee, Sang Hoon

AU - Lee, Yeon Ah

AU - Choe, Jung Yoon

AU - Chung, Won Tae

AU - Suh, Chang Hee

AU - Shim, Seung Cheol

AU - Lee, Jisoo

AU - Yoon, Bo Young

AU - Kim, Dong Wook

AU - Lee, Shin Seok

AU - Yoo, Wan Hee

AU - Kim, Jin Seok

AU - Jung, Young Ok

AU - Nah, Seong Su

AU - Lee, Choong Ki

AU - Song, Gwan Gyu

AU - Choi, Sungjae

AU - Joung, Chung Il

AU - Koh, Hyein

AU - Kim, Young Joo

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Aim: To determine characteristics of rheumatoid arthritis (RA) patients in Korea using disease-modifying anti-rheumatic drugs (DMARDs) for at least 6 months, and to identify factors associated with poor health-related outcomes. Method: A total of 2000 RA patients aged > 20 years, treated with DMARDs for at least 6 months, and signed informed consent, were enrolled in this non-interventional, multicenter, cross-sectional observational study from December 2012 to June 2013. Health-related quality of life (HRQoL) was measured using EuroQuol 5D (EQ-5D) and functional disability was measured using the Korean Health Assessment Questionnaire (KHAQ). Univariate and multivariate linear regression analyses were used to determine the association between patient characteristics and patient-reported outcomes (PROs). Results: Of all RA patients, 84% were female, patients with low Disease Activity Score of 28 joints erythrocyte sedimentation rate (DAS-28-ESR < 3.2) was 54%, while moderate (DAS-28-ESR 3.2-5.1) and high disease activity score (DAS-28-ESR > 5.1) were 38% and 7.6%, respectively. Mean EQ-5D index score and KHAQ score were 0.6 ± 0.28 and 0.7 ± 0.67, respectively. In multivariate analysis with both PROs, average HRQoL and functional disability score appeared to be worse in persons with older age compared to younger age (P < 0.001), and worse in females compared to males (P < 0.001). Compared to patients having lower DAS (< 3.2), those with moderate and highest DAS (3.2-5.1 and > 5.1) had worse outcome measures (P < 0.001). Conclusion: In this study, higher DAS was one of the most influential factors for poor PROs among all other factors. Therefore, we could suggest appropriate treatment approaches according to DAS along with other significantly associated factors with PROs in the early stage of RA.

AB - Aim: To determine characteristics of rheumatoid arthritis (RA) patients in Korea using disease-modifying anti-rheumatic drugs (DMARDs) for at least 6 months, and to identify factors associated with poor health-related outcomes. Method: A total of 2000 RA patients aged > 20 years, treated with DMARDs for at least 6 months, and signed informed consent, were enrolled in this non-interventional, multicenter, cross-sectional observational study from December 2012 to June 2013. Health-related quality of life (HRQoL) was measured using EuroQuol 5D (EQ-5D) and functional disability was measured using the Korean Health Assessment Questionnaire (KHAQ). Univariate and multivariate linear regression analyses were used to determine the association between patient characteristics and patient-reported outcomes (PROs). Results: Of all RA patients, 84% were female, patients with low Disease Activity Score of 28 joints erythrocyte sedimentation rate (DAS-28-ESR < 3.2) was 54%, while moderate (DAS-28-ESR 3.2-5.1) and high disease activity score (DAS-28-ESR > 5.1) were 38% and 7.6%, respectively. Mean EQ-5D index score and KHAQ score were 0.6 ± 0.28 and 0.7 ± 0.67, respectively. In multivariate analysis with both PROs, average HRQoL and functional disability score appeared to be worse in persons with older age compared to younger age (P < 0.001), and worse in females compared to males (P < 0.001). Compared to patients having lower DAS (< 3.2), those with moderate and highest DAS (3.2-5.1 and > 5.1) had worse outcome measures (P < 0.001). Conclusion: In this study, higher DAS was one of the most influential factors for poor PROs among all other factors. Therefore, we could suggest appropriate treatment approaches according to DAS along with other significantly associated factors with PROs in the early stage of RA.

KW - Disease Activity Score

KW - EuroQol EQ-5D

KW - Korean Health Assessment Questionnaire

KW - Patient-reported outcomes

KW - Quality of life

KW - Rheumatoid arthritis

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