Factors associated with rebleeding in patients with peptic ulcer bleeding: Analysis of the Korean peptic ulcer bleeding (K-PUB) study

Joon Sung Kim, Byung Wook Kim, Sung Min Park, Ki Nam Shim, Seong Woo Jeon, Sang Wook Kim, Yong Chan Lee, Hee Seok Moon, Si Hyung Lee, Woon Tae Jung, Jin Il Kim, Kyoung Oh Kim, Jong Jae Park, Woo Chul Chung, Jeong Hwan Kim, Gwang Ho Baik, Jung Hwan Oh, Sun Moon Kim, Hyun Soo Kim, Chang Heon YangJin Tae Jung, Chul Hyun Lim, Hyun Joo Song, Yong Sik Kim, Gwang Ha Kim, Jie Hyun Kim, Jae Il Chung, Jun Haeng Lee, Min Ho Choi, Jong Kyoung Choi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalGut and Liver
Volume12
Issue number3
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Peptic Ulcer
Hemorrhage
Hematemesis
Gastrointestinal Hemorrhage
Korea
Registries
Mortality
Albumins
Multivariate Analysis
Morbidity
Proton Pump Inhibitors
Pharmaceutical Preparations
Databases
Incidence

Keywords

  • Peptic ulcer hemorrhage
  • Rebleeding
  • Risk factors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Kim, J. S., Kim, B. W., Park, S. M., Shim, K. N., Jeon, S. W., Kim, S. W., ... Choi, J. K. (2018). Factors associated with rebleeding in patients with peptic ulcer bleeding: Analysis of the Korean peptic ulcer bleeding (K-PUB) study. Gut and Liver, 12(3), 271-277. https://doi.org/10.5009/gnl17138

Factors associated with rebleeding in patients with peptic ulcer bleeding : Analysis of the Korean peptic ulcer bleeding (K-PUB) study. / Kim, Joon Sung; Kim, Byung Wook; Park, Sung Min; Shim, Ki Nam; Jeon, Seong Woo; Kim, Sang Wook; Lee, Yong Chan; Moon, Hee Seok; Lee, Si Hyung; Jung, Woon Tae; Kim, Jin Il; Kim, Kyoung Oh; Park, Jong Jae; Chung, Woo Chul; Kim, Jeong Hwan; Baik, Gwang Ho; Oh, Jung Hwan; Kim, Sun Moon; Kim, Hyun Soo; Yang, Chang Heon; Jung, Jin Tae; Lim, Chul Hyun; Song, Hyun Joo; Kim, Yong Sik; Kim, Gwang Ha; Kim, Jie Hyun; Chung, Jae Il; Lee, Jun Haeng; Choi, Min Ho; Choi, Jong Kyoung.

In: Gut and Liver, Vol. 12, No. 3, 01.05.2018, p. 271-277.

Research output: Contribution to journalArticle

Kim, JS, Kim, BW, Park, SM, Shim, KN, Jeon, SW, Kim, SW, Lee, YC, Moon, HS, Lee, SH, Jung, WT, Kim, JI, Kim, KO, Park, JJ, Chung, WC, Kim, JH, Baik, GH, Oh, JH, Kim, SM, Kim, HS, Yang, CH, Jung, JT, Lim, CH, Song, HJ, Kim, YS, Kim, GH, Kim, JH, Chung, JI, Lee, JH, Choi, MH & Choi, JK 2018, 'Factors associated with rebleeding in patients with peptic ulcer bleeding: Analysis of the Korean peptic ulcer bleeding (K-PUB) study', Gut and Liver, vol. 12, no. 3, pp. 271-277. https://doi.org/10.5009/gnl17138
Kim, Joon Sung ; Kim, Byung Wook ; Park, Sung Min ; Shim, Ki Nam ; Jeon, Seong Woo ; Kim, Sang Wook ; Lee, Yong Chan ; Moon, Hee Seok ; Lee, Si Hyung ; Jung, Woon Tae ; Kim, Jin Il ; Kim, Kyoung Oh ; Park, Jong Jae ; Chung, Woo Chul ; Kim, Jeong Hwan ; Baik, Gwang Ho ; Oh, Jung Hwan ; Kim, Sun Moon ; Kim, Hyun Soo ; Yang, Chang Heon ; Jung, Jin Tae ; Lim, Chul Hyun ; Song, Hyun Joo ; Kim, Yong Sik ; Kim, Gwang Ha ; Kim, Jie Hyun ; Chung, Jae Il ; Lee, Jun Haeng ; Choi, Min Ho ; Choi, Jong Kyoung. / Factors associated with rebleeding in patients with peptic ulcer bleeding : Analysis of the Korean peptic ulcer bleeding (K-PUB) study. In: Gut and Liver. 2018 ; Vol. 12, No. 3. pp. 271-277.
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abstract = "Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1{\%} of the patients (64), and the 30-day mortality was 1.0{\%} (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.",
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T1 - Factors associated with rebleeding in patients with peptic ulcer bleeding

T2 - Analysis of the Korean peptic ulcer bleeding (K-PUB) study

AU - Kim, Joon Sung

AU - Kim, Byung Wook

AU - Park, Sung Min

AU - Shim, Ki Nam

AU - Jeon, Seong Woo

AU - Kim, Sang Wook

AU - Lee, Yong Chan

AU - Moon, Hee Seok

AU - Lee, Si Hyung

AU - Jung, Woon Tae

AU - Kim, Jin Il

AU - Kim, Kyoung Oh

AU - Park, Jong Jae

AU - Chung, Woo Chul

AU - Kim, Jeong Hwan

AU - Baik, Gwang Ho

AU - Oh, Jung Hwan

AU - Kim, Sun Moon

AU - Kim, Hyun Soo

AU - Yang, Chang Heon

AU - Jung, Jin Tae

AU - Lim, Chul Hyun

AU - Song, Hyun Joo

AU - Kim, Yong Sik

AU - Kim, Gwang Ha

AU - Kim, Jie Hyun

AU - Chung, Jae Il

AU - Lee, Jun Haeng

AU - Choi, Min Ho

AU - Choi, Jong Kyoung

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.

AB - Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.

KW - Peptic ulcer hemorrhage

KW - Rebleeding

KW - Risk factors

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