Factors influencing hepatocellular carcinoma prognosis after hepatectomy: A single-center experience

Sung Keun Park, Young Kul Jung, Dong Hae Chung, Keon Kuk Kim, Yeon Ho Park, Jung Nam Lee, Oh Sang Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Aims: Recurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in patients with HCC after hepatic resection. Methods: This study was of a retrospective cohort design, and 126 patients who underwent hepatic resection for HCC at Gachon University Gil Medical Center between January 2005 and December 2010 were enrolled. Various clinical, laboratory, and pathological data were evaluated to determine the prognostic factors affecting OS and DFS. Results: Two- and 4-year OS and 2- and 4-year DFS were 78.1% and 65% and 51.1% and 26.6%, respectively. In a multivariate analysis, preoperative α-fetoprotein (> 400 ng/mL), tumor size (≥ 5 cm), multiple tumors (two or more nodules), presence of portal vein invasion, modified Union for International Cancer Control (UICC) stage III/IV, and Barcelona Clinic Liver Cancer (BCLC) stage B/C were independent prognostic factors affecting a shorter OS. In the multivariate analysis, presence of microvascular invasion, modified UICC stage III/IV, and BCLC stage B/C were independent prognostic factors for a shorter DFS. Conclusions: The presence of vascular invasion was an independent poor prognostic factor for OS and DFS in patients with HCC after hepatic resection. Thus, close postoperative surveillance for early detection of recurrence and additional treatments are urgently needed in patients with vascular invasion after hepatic resection.

Original languageEnglish
Pages (from-to)428-438
Number of pages11
JournalKorean Journal of Internal Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1
Externally publishedYes

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Hepatectomy
Hepatocellular Carcinoma
Disease-Free Survival
Survival
Liver
Liver Neoplasms
Blood Vessels
Neoplasms
Multivariate Analysis
Fetal Proteins
Recurrence
Portal Vein

Keywords

  • Carcinoma
  • Hepatic resection
  • Hepatocellular
  • Prognosis
  • Vascular invasion

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Factors influencing hepatocellular carcinoma prognosis after hepatectomy : A single-center experience. / Park, Sung Keun; Jung, Young Kul; Chung, Dong Hae; Kim, Keon Kuk; Park, Yeon Ho; Lee, Jung Nam; Kwon, Oh Sang; Kim, Yun Soo; Choi, Duck Joo; Kim, Ju Hyun.

In: Korean Journal of Internal Medicine, Vol. 28, No. 4, 01.07.2013, p. 428-438.

Research output: Contribution to journalArticle

Park, SK, Jung, YK, Chung, DH, Kim, KK, Park, YH, Lee, JN, Kwon, OS, Kim, YS, Choi, DJ & Kim, JH 2013, 'Factors influencing hepatocellular carcinoma prognosis after hepatectomy: A single-center experience', Korean Journal of Internal Medicine, vol. 28, no. 4, pp. 428-438. https://doi.org/10.3904/kjim.2013.28.4.428
Park, Sung Keun ; Jung, Young Kul ; Chung, Dong Hae ; Kim, Keon Kuk ; Park, Yeon Ho ; Lee, Jung Nam ; Kwon, Oh Sang ; Kim, Yun Soo ; Choi, Duck Joo ; Kim, Ju Hyun. / Factors influencing hepatocellular carcinoma prognosis after hepatectomy : A single-center experience. In: Korean Journal of Internal Medicine. 2013 ; Vol. 28, No. 4. pp. 428-438.
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AU - Park, Yeon Ho

AU - Lee, Jung Nam

AU - Kwon, Oh Sang

AU - Kim, Yun Soo

AU - Choi, Duck Joo

AU - Kim, Ju Hyun

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AB - Background/Aims: Recurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in patients with HCC after hepatic resection. Methods: This study was of a retrospective cohort design, and 126 patients who underwent hepatic resection for HCC at Gachon University Gil Medical Center between January 2005 and December 2010 were enrolled. Various clinical, laboratory, and pathological data were evaluated to determine the prognostic factors affecting OS and DFS. Results: Two- and 4-year OS and 2- and 4-year DFS were 78.1% and 65% and 51.1% and 26.6%, respectively. In a multivariate analysis, preoperative α-fetoprotein (> 400 ng/mL), tumor size (≥ 5 cm), multiple tumors (two or more nodules), presence of portal vein invasion, modified Union for International Cancer Control (UICC) stage III/IV, and Barcelona Clinic Liver Cancer (BCLC) stage B/C were independent prognostic factors affecting a shorter OS. In the multivariate analysis, presence of microvascular invasion, modified UICC stage III/IV, and BCLC stage B/C were independent prognostic factors for a shorter DFS. Conclusions: The presence of vascular invasion was an independent poor prognostic factor for OS and DFS in patients with HCC after hepatic resection. Thus, close postoperative surveillance for early detection of recurrence and additional treatments are urgently needed in patients with vascular invasion after hepatic resection.

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