Factors influencing the severity of acute viral hepatitis A.

Joo Il Kim, Yun Soo Kim, Young Kul Jung, Oh Sang Kwon, Yeon Suk Kim, Yang Suh Ku, Duck Joo Choi, Ju Hyun Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Most patients with acute viral hepatitis A have a favorable course, but a few of them suffer from severe forms of hepatitis such as fulminant hepatitis. This study was carried out to identify the factors influencing the severity of acute viral hepatitis A. We retrospectively reviewed the medical records of 713 patients with acute hepatitis A, who were divided into two groups: severe hepatitis A (N=87) and non-severe hepatitis A (N=626). Severe hepatitis was defined as fulminant hepatitis or prolongation of prothrombin time (INR≥1.5). Clinical variables were compared between the two groups. The incidence of fulminant hepatitis was 1.4 % (10/713) in patients with acute hepatitis A. Thirty-three (4.6 %) cases exhibited HBsAg positivity. In multivariate analyses, significant alcohol intake and the presence of HBsAg were significant predictive factors of fulminant hepatitis A, and significant alcohol intake and age were significant predictive factors of severe hepatitis A. HBeAg and HBV-DNA status did not affect the clinical course of hepatitis A in chronic hepatitis B carriers. While most patients with acute hepatitis A have an uncomplicated clinical course, our data suggest that a more-severe clinical course is correlated with being older, significant alcohol intake, and chronic hepatitis-B-virus infection.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalThe Korean journal of hepatology
Volume16
Issue number3
Publication statusPublished - 2010 Sep 1
Externally publishedYes

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Hepatitis A
Hepatitis
Alcohols
Chronic Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B e Antigens
Prothrombin Time
Virus Diseases
Hepatitis B virus
Medical Records
Multivariate Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kim, J. I., Kim, Y. S., Jung, Y. K., Kwon, O. S., Kim, Y. S., Ku, Y. S., ... Kim, J. H. (2010). Factors influencing the severity of acute viral hepatitis A. The Korean journal of hepatology, 16(3), 295-300.

Factors influencing the severity of acute viral hepatitis A. / Kim, Joo Il; Kim, Yun Soo; Jung, Young Kul; Kwon, Oh Sang; Kim, Yeon Suk; Ku, Yang Suh; Choi, Duck Joo; Kim, Ju Hyun.

In: The Korean journal of hepatology, Vol. 16, No. 3, 01.09.2010, p. 295-300.

Research output: Contribution to journalArticle

Kim, JI, Kim, YS, Jung, YK, Kwon, OS, Kim, YS, Ku, YS, Choi, DJ & Kim, JH 2010, 'Factors influencing the severity of acute viral hepatitis A.', The Korean journal of hepatology, vol. 16, no. 3, pp. 295-300.
Kim JI, Kim YS, Jung YK, Kwon OS, Kim YS, Ku YS et al. Factors influencing the severity of acute viral hepatitis A. The Korean journal of hepatology. 2010 Sep 1;16(3):295-300.
Kim, Joo Il ; Kim, Yun Soo ; Jung, Young Kul ; Kwon, Oh Sang ; Kim, Yeon Suk ; Ku, Yang Suh ; Choi, Duck Joo ; Kim, Ju Hyun. / Factors influencing the severity of acute viral hepatitis A. In: The Korean journal of hepatology. 2010 ; Vol. 16, No. 3. pp. 295-300.
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