Failure of topical DMSO to improve blood flow or evoked potentials in rat spinal cord injury

Youn-Kwan Park, Charles H. Tator

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dimethyl sulfoxide (DMSO) is a well-known hydroxyl radical scavenger, which is readily absorbed through biological membranes. We studied the effects of locally applied DMSO on acute spinal cord injury. Either 10% DMSO in saline (n=8) or saline alone (n=7) was applied directly to the exposed cervical spinal cord of rats 1 hour after clip compression injury of 26 g force for 1 minute. The outcomes measured were spinal cord blood flow and evoked potentials. Spinal cord blood flow was not significantly different between these two groups. Although the evoked potentials showed spontaneous recovery after injury, there was no significant difference between the groups. In this study we failed to show any beneficial effects from topical application of high-dose DMSO on spinal cord blood flow or evoked potentials after acute spinal cord injury.

Original languageEnglish
Pages (from-to)638-644
Number of pages7
JournalJournal of Korean Medical Science
Volume13
Issue number6
Publication statusPublished - 1998 Dec 1

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Keywords

  • Administration, topical
  • Dimethyl sulfoxide
  • Evoked potentials
  • Regional blood flow
  • Spinal cord injuries

ASJC Scopus subject areas

  • Medicine(all)

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