Failure of topical DMSO to improve blood flow or evoked potentials in rat spinal cord injury

Youn Kwan Park, Charles H. Tator

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Dimethyl sulfoxide (DMSO) is a well-known hydroxyl radical scavenger, which is readily absorbed through biological membranes. We studied the effects of locally applied DMSO on acute spinal cord injury. Either 10% DMSO in saline (n=8) or saline alone (n=7) was applied directly to the exposed cervical spinal cord of rats 1 hour after clip compression injury of 26 g force for 1 minute. The outcomes measured were spinal cord blood flow and evoked potentials. Spinal cord blood flow was not significantly different between these two groups. Although the evoked potentials showed spontaneous recovery after injury, there was no significant difference between the groups. In this study we failed to show any beneficial effects from topical application of high-dose DMSO on spinal cord blood flow or evoked potentials after acute spinal cord injury.

    Original languageEnglish
    Pages (from-to)638-644
    Number of pages7
    JournalJournal of Korean medical science
    Volume13
    Issue number6
    DOIs
    Publication statusPublished - 1998 Dec

    Keywords

    • Administration, topical
    • Dimethyl sulfoxide
    • Evoked potentials
    • Regional blood flow
    • Spinal cord injuries

    ASJC Scopus subject areas

    • Medicine(all)

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