Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Y. K. Kim, S. H. Kim, S. H. Choi, Y. H. Ko, L. Kim, M. S. Lee, K. Y. Suh, D. I. Kwak, K. J. Song, Y. J. Lee, R. Yanagihara, J. W. Song

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalJournal of NeuroVirology
Volume5
Issue number2
DOIs
Publication statusPublished - 1999

Keywords

  • Borna disease virus
  • PBMC
  • Psychiatric disorders
  • RT-PCR

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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