Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Yong Ku Kim, S. H. Kim, Sang-Hyun Choi, Young-Hoon Ko, Leen Kim, Min-Soo Lee, K. Y. Suh, D. I. Kwak, Ki-Joon Song, Y. J. Lee, R. Yanagihara, Jin Won Song

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalJournal of NeuroVirology
Volume5
Issue number2
Publication statusPublished - 1999 Apr 29

Fingerprint

Borna disease virus
Korea
Psychiatry
Blood Cells
Genome
RNA
Virus Diseases
Mood Disorders
Bipolar Disorder
Open Reading Frames
Reverse Transcription
Schizophrenia
Nucleotides
Depression
Polymerase Chain Reaction
Proteins

Keywords

  • Borna disease virus
  • PBMC
  • Psychiatric disorders
  • RT-PCR

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea. / Kim, Yong Ku; Kim, S. H.; Choi, Sang-Hyun; Ko, Young-Hoon; Kim, Leen; Lee, Min-Soo; Suh, K. Y.; Kwak, D. I.; Song, Ki-Joon; Lee, Y. J.; Yanagihara, R.; Song, Jin Won.

In: Journal of NeuroVirology, Vol. 5, No. 2, 29.04.1999, p. 196-199.

Research output: Contribution to journalArticle

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AU - Lee, Min-Soo

AU - Suh, K. Y.

AU - Kwak, D. I.

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AU - Yanagihara, R.

AU - Song, Jin Won

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