Familial aggregation of the metabolic syndrome in Korean families with adolescents

Hye Soon Park, Jung Yul Park, Sung Il Cho

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We investigated the familial aggregation of the metabolic syndrome in Korean families with adolescents. In a cross-sectional observational study, the body mass index, waist circumference, blood pressure, fasting glucose, serum triglyceride, HDL-cholesterol, total cholesterol and fasting insulin concentrations, and homeostasis model assessment (HOMA) score, were examined in each individual in 132 Korean nuclear families. Most variables of the metabolic syndrome in offspring were significantly correlated with those of parents. Compared with sons, daughters had more significant difference for the metabolic parameters according to clustering of risk factors of their parents. Especially, daughters showed higher correlations with their parents for waist circumference, with their mothers for fasting glucose and HDL-cholesterol, and with their fathers for fasting insulin than sons. Compared with children whose parents did not have the metabolic syndrome, the odds ratios in children with at least one parent with the metabolic syndrome were 4.1 (1.6-10.6) for overweight, 3.6 (1.3-10.2) for abdominal obesity, 5.0 (2.0-12.3) for high triglycerides, and 4.8 (1.1-21.0) for the metabolic syndrome. We also observed significant correlations in variables of the metabolic syndrome between siblings and between spouses. In Korean families with adolescents, there is a familial aggregation of the metabolic syndrome, with daughters resembling their parents more than sons. These findings may have significant implications for clinical interventions directed at adolescents at high risk for the metabolic syndrome.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalAtherosclerosis
Volume186
Issue number1
DOIs
Publication statusPublished - 2006 May 1
Externally publishedYes

Fingerprint

Nuclear Family
Parents
Fasting
Waist Circumference
HDL Cholesterol
Triglycerides
Insulin
Glucose
Abdominal Obesity
Spouses
Fathers
Observational Studies
Cluster Analysis
Siblings
Body Mass Index
Homeostasis
Cross-Sectional Studies
Odds Ratio
Cholesterol
Mothers

Keywords

  • Adolescents
  • Familial aggregation
  • Korean
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Familial aggregation of the metabolic syndrome in Korean families with adolescents. / Park, Hye Soon; Park, Jung Yul; Cho, Sung Il.

In: Atherosclerosis, Vol. 186, No. 1, 01.05.2006, p. 215-221.

Research output: Contribution to journalArticle

Park, Hye Soon ; Park, Jung Yul ; Cho, Sung Il. / Familial aggregation of the metabolic syndrome in Korean families with adolescents. In: Atherosclerosis. 2006 ; Vol. 186, No. 1. pp. 215-221.
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