Abstract
We investigated the familial aggregation of the metabolic syndrome in Korean families with adolescents. In a cross-sectional observational study, the body mass index, waist circumference, blood pressure, fasting glucose, serum triglyceride, HDL-cholesterol, total cholesterol and fasting insulin concentrations, and homeostasis model assessment (HOMA) score, were examined in each individual in 132 Korean nuclear families. Most variables of the metabolic syndrome in offspring were significantly correlated with those of parents. Compared with sons, daughters had more significant difference for the metabolic parameters according to clustering of risk factors of their parents. Especially, daughters showed higher correlations with their parents for waist circumference, with their mothers for fasting glucose and HDL-cholesterol, and with their fathers for fasting insulin than sons. Compared with children whose parents did not have the metabolic syndrome, the odds ratios in children with at least one parent with the metabolic syndrome were 4.1 (1.6-10.6) for overweight, 3.6 (1.3-10.2) for abdominal obesity, 5.0 (2.0-12.3) for high triglycerides, and 4.8 (1.1-21.0) for the metabolic syndrome. We also observed significant correlations in variables of the metabolic syndrome between siblings and between spouses. In Korean families with adolescents, there is a familial aggregation of the metabolic syndrome, with daughters resembling their parents more than sons. These findings may have significant implications for clinical interventions directed at adolescents at high risk for the metabolic syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 186 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2006 May 1 |
| Externally published | Yes |
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Keywords
- Adolescents
- Familial aggregation
- Korean
- Metabolic syndrome
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Familial aggregation of the metabolic syndrome in Korean families with adolescents. / Park, Hye Soon; Park, Jung Yul; Cho, Sung Il.
In: Atherosclerosis, Vol. 186, No. 1, 01.05.2006, p. 215-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial aggregation of the metabolic syndrome in Korean families with adolescents
AU - Park, Hye Soon
AU - Park, Jung Yul
AU - Cho, Sung Il
PY - 2006/5/1
Y1 - 2006/5/1
N2 - We investigated the familial aggregation of the metabolic syndrome in Korean families with adolescents. In a cross-sectional observational study, the body mass index, waist circumference, blood pressure, fasting glucose, serum triglyceride, HDL-cholesterol, total cholesterol and fasting insulin concentrations, and homeostasis model assessment (HOMA) score, were examined in each individual in 132 Korean nuclear families. Most variables of the metabolic syndrome in offspring were significantly correlated with those of parents. Compared with sons, daughters had more significant difference for the metabolic parameters according to clustering of risk factors of their parents. Especially, daughters showed higher correlations with their parents for waist circumference, with their mothers for fasting glucose and HDL-cholesterol, and with their fathers for fasting insulin than sons. Compared with children whose parents did not have the metabolic syndrome, the odds ratios in children with at least one parent with the metabolic syndrome were 4.1 (1.6-10.6) for overweight, 3.6 (1.3-10.2) for abdominal obesity, 5.0 (2.0-12.3) for high triglycerides, and 4.8 (1.1-21.0) for the metabolic syndrome. We also observed significant correlations in variables of the metabolic syndrome between siblings and between spouses. In Korean families with adolescents, there is a familial aggregation of the metabolic syndrome, with daughters resembling their parents more than sons. These findings may have significant implications for clinical interventions directed at adolescents at high risk for the metabolic syndrome.
AB - We investigated the familial aggregation of the metabolic syndrome in Korean families with adolescents. In a cross-sectional observational study, the body mass index, waist circumference, blood pressure, fasting glucose, serum triglyceride, HDL-cholesterol, total cholesterol and fasting insulin concentrations, and homeostasis model assessment (HOMA) score, were examined in each individual in 132 Korean nuclear families. Most variables of the metabolic syndrome in offspring were significantly correlated with those of parents. Compared with sons, daughters had more significant difference for the metabolic parameters according to clustering of risk factors of their parents. Especially, daughters showed higher correlations with their parents for waist circumference, with their mothers for fasting glucose and HDL-cholesterol, and with their fathers for fasting insulin than sons. Compared with children whose parents did not have the metabolic syndrome, the odds ratios in children with at least one parent with the metabolic syndrome were 4.1 (1.6-10.6) for overweight, 3.6 (1.3-10.2) for abdominal obesity, 5.0 (2.0-12.3) for high triglycerides, and 4.8 (1.1-21.0) for the metabolic syndrome. We also observed significant correlations in variables of the metabolic syndrome between siblings and between spouses. In Korean families with adolescents, there is a familial aggregation of the metabolic syndrome, with daughters resembling their parents more than sons. These findings may have significant implications for clinical interventions directed at adolescents at high risk for the metabolic syndrome.
KW - Adolescents
KW - Familial aggregation
KW - Korean
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=33645890571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645890571&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2005.07.019
DO - 10.1016/j.atherosclerosis.2005.07.019
M3 - Article
C2 - 16126214
AN - SCOPUS:33645890571
VL - 186
SP - 215
EP - 221
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -