Family History and Risk of Recurrent Stroke

Jong Won Chung, Beom Joon Kim, Moon Ku Han, Kyusik Kang, Jong Moo Park, Sang Soon Park, Tai Hwan Park, Yong Jin Cho, Keun Sik Hong, Kyung Bok Lee, Jae Guk Kim, Youngchai Ko, Soojoo Lee, Hyun Wook Nah, Dae Hyun Kim, Jae Kwan Cha, Mi Sun Oh, Kyung Ho Yu, Byung Chul Lee, Myung Suk JangJi Sung Lee, Juneyoung Lee, Hee Joon Bae

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10 Citations (Scopus)

Abstract

Background and Purpose - The association between family history of stroke and stroke recurrence remains unclear. Methods - Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and ≥70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke. Results - Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients. Conclusions - This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.

Original languageEnglish
Pages (from-to)1990-1996
Number of pages7
JournalStroke
Volume47
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

Keywords

  • ischemia
  • prognosis
  • proportional hazard models
  • risk assessment
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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    Chung, J. W., Kim, B. J., Han, M. K., Kang, K., Park, J. M., Park, S. S., Park, T. H., Cho, Y. J., Hong, K. S., Lee, K. B., Kim, J. G., Ko, Y., Lee, S., Nah, H. W., Kim, D. H., Cha, J. K., Oh, M. S., Yu, K. H., Lee, B. C., ... Bae, H. J. (2016). Family History and Risk of Recurrent Stroke. Stroke, 47(8), 1990-1996. https://doi.org/10.1161/STROKEAHA.116.013148