Fast tensor image morphing for elastic registration

Pew Thian Yap, Guorong Wu, Hongtu Zhu, Weili Lin, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)


We propose a novel algorithm, called Fast Tensor Image Morphing for Elastic Registration or F-TIMER. F-TIMER leverages multiscale tensor regional distributions and local boundaries for hierarchically driving deformable matching of tensor image volumes. Registration is achieved by aligning a set of automatically determined structural landmarks, via solving a soft correspondence problem. Based on the estimated correspondences, thin-plate splines are employed to generate a smooth, topology preserving, and dense transformation, and to avoid arbitrary mapping of non-landmark voxels. To mitigate the problem of local minima, which is common in the estimation of high dimensional transformations, we employ a hierarchical strategy where a small subset of voxels with more distinctive attribute vectors are first deployed as landmarks to estimate a relatively robust low-degrees-of-freedom transformation. As the registration progresses, an increasing number of voxels are permitted to participate in refining the correspondence matching. A scheme as such allows less conservative progression of the correspondence matching towards the optimal solution, and hence results in a faster matching speed. Results indicate that better accuracy can be achieved by F-TIMER, compared with other deformable registration algorithms [1, 2], with significantly reduced computation time cost of 4-14 folds.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2009 - 12th International Conference, Proceedings
Number of pages9
EditionPART 1
Publication statusPublished - 2009
Externally publishedYes
Event12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009 - London, United Kingdom
Duration: 2009 Sep 202009 Sep 24

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5761 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
Country/TerritoryUnited Kingdom

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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