Fatty acids reduce the tensile strength of fungal hyphae during cephalosporin C production in Acremonium chrysogenum

Jong Chae Kim, Yoon Seok Song, Dong Hwan Lee, Seong Woo Kang, Seung Wook Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)


Fragmentation rate constants, which can be used to estimate the tensile strength of fungal hyphae, were used to elucidate relationships between morphological changes and addition of fatty acids during cephalosporin C production in Acremonium chrysogenum M35. The number of arthrospores increased gradually during fermentation, and, in particular, was higher in the presence of rice oil, oleic acid or linoleic acid than in their absence. Because supplementation of rice oil or fatty acids increased cephalosporin C, we concluded that differentiation to arthrospores is related to cephalosporin C production. To estimate the relative tensile strengths of fungal hyphae, fragmentation rate constants (k frag) were measured. When rice oil, oleic acid, or linoleic acid were added into medium, fragmentation rate constants were higher than for the control, and hyphal tensile strengths reduced. The relative tensile strength of fungal hyphae, however was not constant presumably due to differences in physiological state.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalBiotechnology Letters
Issue number1
Publication statusPublished - 2007 Jan 1



  • Acremonium chrysogenum
  • Fatty acids
  • Fungal hyphae
  • Rice oil
  • Tensile strength

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this