Abstract
The aim of this study was to explore whether polymorphisms of the Fcγ receptors (FcγRs) IIB T/I232 and FcγRIIIB NA1/NA2, confer susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). The authors conducted a meta-analysis on associations between the FcγRIIB T/I232 and FcγRIIIB NA1/NA2 polymorphisms and SLE and LN susceptibility as determined using 1) allele contrast, 2) recessive, 3) dominant models and 4) contrast of homozygotes. A total of 16 separate comparisons were considered, consisting of 2887 SLE patients and 3105 controls. Meta-analysis of the FcγRIIB T/I232 polymorphism showed a significant association between the FcγRIIB T allele and the risk of developing SLE compared with the FcγRIIB I allele (OR = 1.207, 95% Cl = 1.061-1.373, P = 0.004). In subjects of Asian descent, a significant association was observed between the FcγRIIB T allele and SLE (OR = 1.332, 95% CI 1.138-1.558, P < 0.001). However, in Europeans no such association was found. In contrast, no association was found between SLE or LN and the FcγRIIIB NA1/NA2 polymorphism in all subjects, or in European and Asian populations. This meta-analysis shows that the FcγRIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations.
| Original language | English |
|---|---|
| Pages (from-to) | 727-734 |
| Number of pages | 8 |
| Journal | Lupus |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2009 Jun 18 |
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Keywords
- Fc receptors
- Genetic polymorphism
- Meta-analysis
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
Cite this
Fcγ receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis : A meta-analysis. / Lee, Young Ho; Ji, Jong Dae; Song, Gwan Gyu.
In: Lupus, Vol. 18, No. 8, 18.06.2009, p. 727-734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fcγ receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2009/6/18
Y1 - 2009/6/18
N2 - The aim of this study was to explore whether polymorphisms of the Fcγ receptors (FcγRs) IIB T/I232 and FcγRIIIB NA1/NA2, confer susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). The authors conducted a meta-analysis on associations between the FcγRIIB T/I232 and FcγRIIIB NA1/NA2 polymorphisms and SLE and LN susceptibility as determined using 1) allele contrast, 2) recessive, 3) dominant models and 4) contrast of homozygotes. A total of 16 separate comparisons were considered, consisting of 2887 SLE patients and 3105 controls. Meta-analysis of the FcγRIIB T/I232 polymorphism showed a significant association between the FcγRIIB T allele and the risk of developing SLE compared with the FcγRIIB I allele (OR = 1.207, 95% Cl = 1.061-1.373, P = 0.004). In subjects of Asian descent, a significant association was observed between the FcγRIIB T allele and SLE (OR = 1.332, 95% CI 1.138-1.558, P < 0.001). However, in Europeans no such association was found. In contrast, no association was found between SLE or LN and the FcγRIIIB NA1/NA2 polymorphism in all subjects, or in European and Asian populations. This meta-analysis shows that the FcγRIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations.
AB - The aim of this study was to explore whether polymorphisms of the Fcγ receptors (FcγRs) IIB T/I232 and FcγRIIIB NA1/NA2, confer susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). The authors conducted a meta-analysis on associations between the FcγRIIB T/I232 and FcγRIIIB NA1/NA2 polymorphisms and SLE and LN susceptibility as determined using 1) allele contrast, 2) recessive, 3) dominant models and 4) contrast of homozygotes. A total of 16 separate comparisons were considered, consisting of 2887 SLE patients and 3105 controls. Meta-analysis of the FcγRIIB T/I232 polymorphism showed a significant association between the FcγRIIB T allele and the risk of developing SLE compared with the FcγRIIB I allele (OR = 1.207, 95% Cl = 1.061-1.373, P = 0.004). In subjects of Asian descent, a significant association was observed between the FcγRIIB T allele and SLE (OR = 1.332, 95% CI 1.138-1.558, P < 0.001). However, in Europeans no such association was found. In contrast, no association was found between SLE or LN and the FcγRIIIB NA1/NA2 polymorphism in all subjects, or in European and Asian populations. This meta-analysis shows that the FcγRIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations.
KW - Fc receptors
KW - Genetic polymorphism
KW - Meta-analysis
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=67049165185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67049165185&partnerID=8YFLogxK
U2 - 10.1177/0961203309104020
DO - 10.1177/0961203309104020
M3 - Article
C2 - 19502269
AN - SCOPUS:67049165185
VL - 18
SP - 727
EP - 734
JO - Lupus
JF - Lupus
SN - 0961-2033
IS - 8
ER -