Feasibility of deformation-independent tumor-tracking radiotherapy during respiration

Seonkyu Kim, Myonggeun Yoon, Dong Shin, Dongwook Kim, Sangyeob Lee, Se Lee, Sung Park, Sang Song

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To evaluate the feasibility of tumor-tracking radiotherapy that does not consider tumor deformation during respiration. Four-dimensional computed tomography (4D-CT) data, which considers 10 phases of the respiration cycle, were acquired in 4 patients with lung cancer and 4 patients with liver cancer. Initial treatment plans were established at the end of the inhalation phase (phase 1). As a simulation of deformation-free tumor-tracking radiotherapy, the beam center of the initial plan was moved to the tumor center for all other phases, and the tumor shape acquired from phase 1 was used for all 10 phases. The feasibility of this method was analyzed based on assessment of equivalent uniform dose (EUD), homogeneity index (HI) and coverage index (COV). In photon radiation treatment, movement-induced dose reduction was not particularly significant, with 0.5%, 17.3% and 2.8% average variation in EUD, HI and COV, respectively. In proton radiation treatment, movement-induced dose reduction was more significant, with 0.3%, 40.5% and 2.2% average variation in EUD, HI and COV, respectively. Proton treatment is more sensitive to tumor movement than is photon treatment, and that it is reasonable to disregard tumor deformation during photon therapy employing tumor-tracking radiotherapy.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalJournal of Medical Physics
Volume36
Issue number2
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • 4D-CT
  • Deformation
  • real-time tumor tracking
  • respiration

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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