Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease

Eugene Jeong, Sun Young Oh, Kisoo Pahk, Chan Nyoung Lee, Kun Woo Park, Jae Sung Lee, Gi Jeong Cheon, Jae-Gol Choe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. Methods: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. Results: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. Conclusions: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalNuclear Medicine and Molecular Imaging
Volume47
Issue number2
DOIs
Publication statusPublished - 2013 Jun 1

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Parkinson Disease
Occipital Lobe
Cerebellum
Putamen
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

Keywords

  • Dopamine transporter (DAT)
  • F-18 FP-CIT PET
  • Korean statistical probabilistic anatomical map (KSPAM)
  • Parkinson's disease
  • Template-based quantitative analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease. / Jeong, Eugene; Oh, Sun Young; Pahk, Kisoo; Lee, Chan Nyoung; Park, Kun Woo; Lee, Jae Sung; Cheon, Gi Jeong; Choe, Jae-Gol.

In: Nuclear Medicine and Molecular Imaging, Vol. 47, No. 2, 01.06.2013, p. 73-80.

Research output: Contribution to journalArticle

Jeong, Eugene ; Oh, Sun Young ; Pahk, Kisoo ; Lee, Chan Nyoung ; Park, Kun Woo ; Lee, Jae Sung ; Cheon, Gi Jeong ; Choe, Jae-Gol. / Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease. In: Nuclear Medicine and Molecular Imaging. 2013 ; Vol. 47, No. 2. pp. 73-80.
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AU - Oh, Sun Young

AU - Pahk, Kisoo

AU - Lee, Chan Nyoung

AU - Park, Kun Woo

AU - Lee, Jae Sung

AU - Cheon, Gi Jeong

AU - Choe, Jae-Gol

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AB - Purpose: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. Methods: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. Results: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. Conclusions: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.

KW - Dopamine transporter (DAT)

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KW - Korean statistical probabilistic anatomical map (KSPAM)

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KW - Template-based quantitative analysis

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