Femto molar detection of a prostatespecific antigen (PSA) using a dynamic selfexciting nanomechanical cantilever

Jeong Hoon Lee, Kyo Seon Hwang, Ga Young Han, Ki Yong Choi, Dae Sung Yoon, Tae Song Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Methods are described to achieve the quantitative analysis up to femtomolar detection using nanomechanical cantilever. we fabricate a nanomechanical sensor that inherently detects the dynamic response variation of cantilever arrays. Here, the clinical discrimination of PSA Ag-Ab interaction up to femto molar level is accomplished by the resonant frequency shift.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages799-801
Number of pages3
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - 2005 Jan 1
Externally publishedYes
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: 2005 Oct 92005 Oct 13

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period05/10/905/10/13

Fingerprint

Antigens
Dynamic response
Natural frequencies
Sensors
Chemical analysis

Keywords

  • Cantilever
  • Dynamic mode
  • Nanomechanics
  • Protein detection

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Lee, J. H., Hwang, K. S., Han, G. Y., Choi, K. Y., Yoon, D. S., & Kim, T. S. (2005). Femto molar detection of a prostatespecific antigen (PSA) using a dynamic selfexciting nanomechanical cantilever. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 799-801). (Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences; Vol. 1). Transducer Research Foundation.

Femto molar detection of a prostatespecific antigen (PSA) using a dynamic selfexciting nanomechanical cantilever. / Lee, Jeong Hoon; Hwang, Kyo Seon; Han, Ga Young; Choi, Ki Yong; Yoon, Dae Sung; Kim, Tae Song.

Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Transducer Research Foundation, 2005. p. 799-801 (Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, JH, Hwang, KS, Han, GY, Choi, KY, Yoon, DS & Kim, TS 2005, Femto molar detection of a prostatespecific antigen (PSA) using a dynamic selfexciting nanomechanical cantilever. in Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, vol. 1, Transducer Research Foundation, pp. 799-801, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005, Boston, MA, United States, 05/10/9.
Lee JH, Hwang KS, Han GY, Choi KY, Yoon DS, Kim TS. Femto molar detection of a prostatespecific antigen (PSA) using a dynamic selfexciting nanomechanical cantilever. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Transducer Research Foundation. 2005. p. 799-801. (Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
Lee, Jeong Hoon ; Hwang, Kyo Seon ; Han, Ga Young ; Choi, Ki Yong ; Yoon, Dae Sung ; Kim, Tae Song. / Femto molar detection of a prostatespecific antigen (PSA) using a dynamic selfexciting nanomechanical cantilever. Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Transducer Research Foundation, 2005. pp. 799-801 (Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
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