Fermented green tea extract alleviates obesity and related complications and alters gut microbiota composition in diet-induced obese mice

Dae Bang Seo, Hyun Woo Jeong, Donghyun Cho, Bum Jin Lee, Ji Hae Lee, Jae Young Choi, Il Hong Bae, Sung-Joon Lee

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Obesity is caused by an imbalance between caloric intake and energy expenditure and accumulation of excess lipids in adipose tissues. Recent studies have demonstrated that green tea and its processed products (e.g., oolong and black tea) are introduced to exert beneficial effects on lipid metabolism. Here, we propose that fermented green tea (FGT) extract, as a novel processed green tea, exhibits antiobesity effects. FGT reduced body weight gain and fat mass without modifying food intake. mRNA expression levels of lipogenic and inflammatory genes were downregulated in white adipose tissue of FGT-administered mice. FGT treatment alleviated glucose intolerance and fatty liver symptoms, common complications of obesity. Notably, FGT restored the changes in gut microbiota composition (e.g., the Firmicutes/Bacteroidetes and Bacteroides/Prevotella ratios), which is reported to be closely related with the development of obesity and insulin resistance, induced by high-fat diets. Collectively, FGT improves obesity and its associated symptoms and modulates composition of gut microbiota; thus, it could be used as a novel dietary component to control obesity and related symptoms.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalJournal of Medicinal Food
Volume18
Issue number5
DOIs
Publication statusPublished - 2015 May 1

Fingerprint

Obese Mice
Tea
Obesity
Diet
Adipose Tissue
Prevotella
Bacteroidetes
Gastrointestinal Microbiome
White Adipose Tissue
Bacteroides
Glucose Intolerance
High Fat Diet
Fatty Liver
Energy Intake
Lipid Metabolism
Energy Metabolism
Weight Gain
Insulin Resistance
Down-Regulation
Eating

Keywords

  • fatty liver
  • green tea
  • health functional food
  • insulin resistance
  • obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Fermented green tea extract alleviates obesity and related complications and alters gut microbiota composition in diet-induced obese mice. / Seo, Dae Bang; Jeong, Hyun Woo; Cho, Donghyun; Lee, Bum Jin; Lee, Ji Hae; Choi, Jae Young; Bae, Il Hong; Lee, Sung-Joon.

In: Journal of Medicinal Food, Vol. 18, No. 5, 01.05.2015, p. 549-556.

Research output: Contribution to journalArticle

Seo, Dae Bang ; Jeong, Hyun Woo ; Cho, Donghyun ; Lee, Bum Jin ; Lee, Ji Hae ; Choi, Jae Young ; Bae, Il Hong ; Lee, Sung-Joon. / Fermented green tea extract alleviates obesity and related complications and alters gut microbiota composition in diet-induced obese mice. In: Journal of Medicinal Food. 2015 ; Vol. 18, No. 5. pp. 549-556.
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