Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure

Dae Bang Seo, Hyun Woo Jeong, Yeon Ji Kim, Sukyung Kim, Jeongkee Kim, Ji Hae Lee, Kyungmi Joo, Jin Kyu Choi, Song Seok Shin, Sung-Joon Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hyperlipidaemia is a major cause of atherosclerosis and related CVD and can be prevented with natural substances. Previously, we reported that a novel Bacillus-fermented green tea (FGT) exerts anti-obesity and hypolipidaemic effects. This study further investigated the hypotriglyceridaemic and anti-obesogenic effects of FGT and its underlying mechanisms. FGT effectively inhibited pancreatic lipase activity in vitro (IC50, 0·48 mg/ml) and ameliorated postprandial lipaemia in rats (26 % reduction with 500 mg/kg FGT). In hypertriglyceridaemic hamsters, FGT administration significantly reduced plasma TAG levels. In mice, FGT administration (500 mg/kg) for 2 weeks augmented energy expenditure by 22 % through the induction of plasma serotonin, a neurotransmitter that modulates energy expenditure and mRNA expressions of lipid metabolism genes in peripheral tissues. Analysis of the gut microbiota showed that FGT reduced the proportion of the phylum Firmicutes in hamsters, which could further contribute to its anti-obesity effects. Collectively, these data demonstrate that FGT decreases plasma TAG levels via multiple mechanisms including inhibition of pancreatic lipase, augmentation of energy expenditure, induction of serotonin secretion and alteration of gut microbiota. These results suggest that FGT may be a useful natural agent for preventing hypertriglyceridaemia and obesity.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalBritish Journal of Nutrition
Volume117
Issue number2
DOIs
Publication statusPublished - 2017 Jan 28

Fingerprint

Tea
Lipase
Energy Metabolism
Obesity
Cricetinae
Serotonin
Hypertriglyceridemia
Hyperlipidemias
Lipid Metabolism
Bacillus
Inhibitory Concentration 50
Neurotransmitter Agents
Atherosclerosis
Messenger RNA

Keywords

  • Energy expenditure
  • Fermented green tea
  • Gut microbiota
  • Hyperlipidaemia
  • Pancreatic lipase
  • Serotonin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure. / Seo, Dae Bang; Jeong, Hyun Woo; Kim, Yeon Ji; Kim, Sukyung; Kim, Jeongkee; Lee, Ji Hae; Joo, Kyungmi; Choi, Jin Kyu; Shin, Song Seok; Lee, Sung-Joon.

In: British Journal of Nutrition, Vol. 117, No. 2, 28.01.2017, p. 177-186.

Research output: Contribution to journalArticle

Seo, Dae Bang ; Jeong, Hyun Woo ; Kim, Yeon Ji ; Kim, Sukyung ; Kim, Jeongkee ; Lee, Ji Hae ; Joo, Kyungmi ; Choi, Jin Kyu ; Shin, Song Seok ; Lee, Sung-Joon. / Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure. In: British Journal of Nutrition. 2017 ; Vol. 117, No. 2. pp. 177-186.
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