Ferroptosis-related genes in neurodevelopment and central nervous system

Soo Whee Kim, Yujin Kim, Sung Eun Kim, Joon Yong An

Research output: Contribution to journalReview articlepeer-review

Abstract

Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.

Original languageEnglish
Article number35
Pages (from-to)1-18
Number of pages18
JournalBiology
Volume10
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Keywords

  • Brain development
  • CNS
  • Ferroptosis
  • Iron
  • Lipid peroxides
  • Neurological disorder

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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