Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

Mi Jeong Kim, Soo Jung Choi, Seung Taik Lim, Hye Kyung Kim, Ho Jin Heo, Eun Ki Kim, Woo Jin Jun, Hong Yon Cho, Young Jun Kim, Dong Hoon Shin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

Original languageEnglish
Pages (from-to)1063-1068
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number4
DOIs
Publication statusPublished - 2007 May 1

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ferulic acid
Acids
mice
Short-Term Memory
Data storage equipment
Chemical activation
dementia
acid treatment
cognition
Cognition
Dementia
trimethyltin
acids

Keywords

  • Choline acetyltransferase
  • Cognitive function
  • Ferulic acid (4-hydroxy-3-methoxycinnamic acid)
  • Trimethyltin

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice. / Kim, Mi Jeong; Choi, Soo Jung; Lim, Seung Taik; Kim, Hye Kyung; Heo, Ho Jin; Kim, Eun Ki; Jun, Woo Jin; Cho, Hong Yon; Kim, Young Jun; Shin, Dong Hoon.

In: Bioscience, Biotechnology and Biochemistry, Vol. 71, No. 4, 01.05.2007, p. 1063-1068.

Research output: Contribution to journalArticle

Kim, MJ, Choi, SJ, Lim, ST, Kim, HK, Heo, HJ, Kim, EK, Jun, WJ, Cho, HY, Kim, YJ & Shin, DH 2007, 'Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice', Bioscience, Biotechnology and Biochemistry, vol. 71, no. 4, pp. 1063-1068. https://doi.org/10.1271/bbb.60564
Kim, Mi Jeong ; Choi, Soo Jung ; Lim, Seung Taik ; Kim, Hye Kyung ; Heo, Ho Jin ; Kim, Eun Ki ; Jun, Woo Jin ; Cho, Hong Yon ; Kim, Young Jun ; Shin, Dong Hoon. / Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice. In: Bioscience, Biotechnology and Biochemistry. 2007 ; Vol. 71, No. 4. pp. 1063-1068.
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