Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

Mi Jeong Kim, Soo Jung Choi, Seung Taik Lim, Hye Kyung Kim, Ho Jin Heo, Eun Ki Kim, Woo Jin Jun, Hong Yon Cho, Young Jun Kim, Dong Hoon Shin

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37 Citations (Scopus)

Abstract

This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

Original languageEnglish
Pages (from-to)1063-1068
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number4
DOIs
Publication statusPublished - 2007

Keywords

  • Choline acetyltransferase
  • Cognitive function
  • Ferulic acid (4-hydroxy-3-methoxycinnamic acid)
  • Trimethyltin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Kim, M. J., Choi, S. J., Lim, S. T., Kim, H. K., Heo, H. J., Kim, E. K., Jun, W. J., Cho, H. Y., Kim, Y. J., & Shin, D. H. (2007). Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice. Bioscience, Biotechnology and Biochemistry, 71(4), 1063-1068. https://doi.org/10.1271/bbb.60564