Fiber modeling and clustering based on neuroanatomical features

Qian Wang, Pew Thian Yap, Guorong Wu, Dinggang Shen

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

DTI tractography allows unprecedented understanding of brain neural connectivity in-vivo by capturing water diffusion patterns in brain white-matter microstructures. However, tractography algorithms often output hundreds of thousands of fibers, rendering the computation needed for subsequent data analysis intractable. A remedy is to group the fibers into bundles using fiber clustering techniques. Most existing fiber clustering methods, however, rely on fiber geometrical information only by viewing fibers as curves in the 3D Euclidean space. The important neuroanatomical aspect of the fibers is mostly ignored. In this paper, neuroanatomical information is encapsulated in a feature vector called the associativity vector, which functions as the "fingerprint" for each fiber and depicts the connectivity of the fiber with respect to individual anatomies. Using the associativity vectors of fibers, we model the fibers as observations sampled from multivariate Gaussian mixtures in the feature space. An expectation-maximization clustering approach is then employed to group the fibers into 16 major bundles. Experimental results indicate that the proposed method groups the fibers into anatomically meaningful bundles, which are highly consistent across subjects.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6892 LNCS
Issue numberPART 2
DOIs
Publication statusPublished - 2011
Event14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011 - Toronto, ON, Canada
Duration: 2011 Sep 182011 Sep 22

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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