Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration

Tae Sik Jang, Eun Jung Lee, Ji Hoon Jo, Jong Myeong Jeon, Mi Young Kim, Hyoun Ee Kim, Young-Hag Koh

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40%. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR.

Original languageEnglish
Pages (from-to)321-330
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume100 B
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Fingerprint

Fibrous membranes
Xerogels
Bone Regeneration
Lactic acid
Silicon Dioxide
Bone
Silica
Membranes
Nanofibers
Tensile Strength
Elastic Modulus
Hybrid materials
Electrospinning
Polymethyl Methacrylate
Sols
poly(lactic acid)
Rats
Cultured Cells
Animals
Tensile strength

Keywords

  • electrospinning
  • guided bone regeneration
  • hybrid membrane
  • poly(L-lactic acid)
  • silica xerogel

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration. / Jang, Tae Sik; Lee, Eun Jung; Jo, Ji Hoon; Jeon, Jong Myeong; Kim, Mi Young; Kim, Hyoun Ee; Koh, Young-Hag.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 100 B, No. 2, 01.02.2012, p. 321-330.

Research output: Contribution to journalArticle

Jang, Tae Sik ; Lee, Eun Jung ; Jo, Ji Hoon ; Jeon, Jong Myeong ; Kim, Mi Young ; Kim, Hyoun Ee ; Koh, Young-Hag. / Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration. In: Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2012 ; Vol. 100 B, No. 2. pp. 321-330.
@article{d225e0b469bf4014b7bf54e747e61821,
title = "Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration",
abstract = "Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40{\%}. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR.",
keywords = "electrospinning, guided bone regeneration, hybrid membrane, poly(L-lactic acid), silica xerogel",
author = "Jang, {Tae Sik} and Lee, {Eun Jung} and Jo, {Ji Hoon} and Jeon, {Jong Myeong} and Kim, {Mi Young} and Kim, {Hyoun Ee} and Young-Hag Koh",
year = "2012",
month = "2",
day = "1",
doi = "10.1002/jbm.b.31952",
language = "English",
volume = "100 B",
pages = "321--330",
journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",
issn = "1552-4973",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration

AU - Jang, Tae Sik

AU - Lee, Eun Jung

AU - Jo, Ji Hoon

AU - Jeon, Jong Myeong

AU - Kim, Mi Young

AU - Kim, Hyoun Ee

AU - Koh, Young-Hag

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40%. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR.

AB - Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40%. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR.

KW - electrospinning

KW - guided bone regeneration

KW - hybrid membrane

KW - poly(L-lactic acid)

KW - silica xerogel

UR - http://www.scopus.com/inward/record.url?scp=84855440784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855440784&partnerID=8YFLogxK

U2 - 10.1002/jbm.b.31952

DO - 10.1002/jbm.b.31952

M3 - Article

C2 - 22102608

AN - SCOPUS:84855440784

VL - 100 B

SP - 321

EP - 330

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

SN - 1552-4973

IS - 2

ER -