Film and pharmaceutical hard capsule formation properties of mungbean, waterchestnut, and sweet potato starches

Ho J. Bae, Dong S. Cha, William S. Whiteside, Hyun Jin Park

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Biodegradable films were developed using mungbean, waterchestnut and sweet potato starches as base raw materials. The physical and mechanical properties of the films were compared with gelatin and HPMC films. The same starches were used to develop hard capsules for utilization in the pharmaceutical industry as a substitute for gelatin or animal based products. Starches with high amylose content had excellent film and hard capsule forming abilities and properties compared to the starches with low amylase content. The starch films also had excellent oxygen barrier properties (0.048 ± 0.008 to 0.070 ± 0.009 fl m/m2 s Pa), but water barrier properties (1.1 ± 0.5 to 1.8 ± 0.4 ng m/m2 s Pa) were higher than LDPE (0.00064 ng m/m2 s Pa) synthetic polymer films. The tensile strength values of starch films (12.1 ± 0.7 to 19.0 ± 2.2 MPa) were not significantly different from gelatin (19.5 ± 1.6 MPa) and HPMC (19.9 ± 1.2 MPa) films. In the case of elongation properties, starch films had lower values (42.2 ± 7.7 to 79.4 ± 9.2%) than gelatin film (122.0 ± 14.6%), but higher than HPMC film (13.8 ± 4.2%). Molecular (SEC-MALLS) and physical (viscosity) characterization of vegetable starches, indicated that the starches with high amylose content produced better biopolymer films and capsules compared to the starches with low amylose and high amylopectin content. Biodegradable films and hard capsules for pharmaceutical applications could be developed from vegetable starches with similar physical and mechanical properties as synthetic and gelatin products.

Original languageEnglish
Pages (from-to)96-105
Number of pages10
JournalFood Chemistry
Volume106
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

Fingerprint

Ipomoea batatas
mung beans
films (materials)
Starch
Capsules
drugs
starch
Pharmaceutical Preparations
gelatin
Gelatin
Amylose
amylose
Vegetables
biodegradability
sweet potato starch
Physical properties
mechanical properties
physical properties
Amylopectin
vegetables

Keywords

  • Amylose
  • Film
  • Gelatin
  • Hard capsule
  • HPMC
  • SEC-MALLS
  • Starch

ASJC Scopus subject areas

  • Food Science

Cite this

Film and pharmaceutical hard capsule formation properties of mungbean, waterchestnut, and sweet potato starches. / Bae, Ho J.; Cha, Dong S.; Whiteside, William S.; Park, Hyun Jin.

In: Food Chemistry, Vol. 106, No. 1, 01.01.2008, p. 96-105.

Research output: Contribution to journalArticle

Bae, Ho J. ; Cha, Dong S. ; Whiteside, William S. ; Park, Hyun Jin. / Film and pharmaceutical hard capsule formation properties of mungbean, waterchestnut, and sweet potato starches. In: Food Chemistry. 2008 ; Vol. 106, No. 1. pp. 96-105.
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