Finding the best treatment under heavy censoring and hidden bias

Myoung-jae Lee, Unto Häkkinen, Gunnar Rosenqvist

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We analyse male survival duration after hospitalization following an acute myocardial infarction with a large (N = 11024) Finnish data set to find the best performing hospital district (and to disseminate its treatment protocol).This is a multiple-treatment problem with 21 treatments (i.e. 21 hospital districts).The task of choosing the best treatment is difficult owing to heavy right censoring (73%), which makes the usual location measures (the mean and median) unidentified; instead, only lower quantiles are identified. There is also a sample selection issue that only those who made it to a hospital alive are observed (54%); this becomes a problem if we wish to know their potential survival duration after hospitalization, if they had survived to a hospital contrary to the fact. The data set is limited in its covariates - only age is available - but includes the distance to the hospital, which plays an interesting role. Given that only age and distance are observed, it is likely that there are unobserved confounders. To account for them, a sensitivity analysis is conducted following pair matching. All estimators employed point to a clear winner and the sensitivity analysis indicates that the finding is fairly robust.

Original languageEnglish
Pages (from-to)133-147
Number of pages15
JournalJournal of the Royal Statistical Society. Series A: Statistics in Society
Volume170
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

Fingerprint

Censoring
trend
hospitalization
Sensitivity Analysis
district
Sample Selection
Acute Myocardial Infarction
Right Censoring
Quantile
Covariates
Likely
Estimator
Sensitivity analysis
Hospitalization

Keywords

  • Censored model
  • Matching
  • Quantile regression
  • Sensitivity analysis

ASJC Scopus subject areas

  • Statistics and Probability
  • Economics and Econometrics
  • Social Sciences (miscellaneous)

Cite this

Finding the best treatment under heavy censoring and hidden bias. / Lee, Myoung-jae; Häkkinen, Unto; Rosenqvist, Gunnar.

In: Journal of the Royal Statistical Society. Series A: Statistics in Society, Vol. 170, No. 1, 01.01.2007, p. 133-147.

Research output: Contribution to journalArticle

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