TY - JOUR
T1 - Fingerprinting differentiation of Astragalus membranaceus roots according to ages using 1H-NMR spectroscopy and multivariate statistical analysis
AU - Shin, Yoo Soo
AU - Bang, Kyong Hwan
AU - In, Dong Su
AU - Sung, Jung Sook
AU - Kim, Seon Young
AU - Ku, Bon Cho
AU - Kim, Suk Weon
AU - Lee, Dongho
AU - Choi, Hyung Kyoon
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/4
Y1 - 2009/4
N2 - The root of Astragalus membranaceus is a traditional folk medicine that has been used for many therapeutic purposes in Asia. It reportedly acts as an immunostimulant, tonic, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, sedative, and anticancer drug. In this study, metabolomic profiling was applied to the roots of A. membranaceus of different ages using NMR coupled with two multivariate statistical analysis methods: such as principal components analysis (PCA) and canonical discriminant analysis (CDA). This allowed various metabolites to be assigned in NMR spectra, including γ-aminobutyric acid (GABA), aspartic acid, succinic acid, glutamic acid, glutamine, N-acetyl aspartic acid, acetic acid, arginine, alanine, threonine, lactic acid, and valine. The score plot from PCA and also CDA allowed a clear separation between samples according to age.
AB - The root of Astragalus membranaceus is a traditional folk medicine that has been used for many therapeutic purposes in Asia. It reportedly acts as an immunostimulant, tonic, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, sedative, and anticancer drug. In this study, metabolomic profiling was applied to the roots of A. membranaceus of different ages using NMR coupled with two multivariate statistical analysis methods: such as principal components analysis (PCA) and canonical discriminant analysis (CDA). This allowed various metabolites to be assigned in NMR spectra, including γ-aminobutyric acid (GABA), aspartic acid, succinic acid, glutamic acid, glutamine, N-acetyl aspartic acid, acetic acid, arginine, alanine, threonine, lactic acid, and valine. The score plot from PCA and also CDA allowed a clear separation between samples according to age.
KW - Astragalus membranaceus
KW - Canonical discriminant analysis
KW - Fingerprinting analysis
KW - H NMR spectroscopy
KW - Principal component analysis
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U2 - 10.4062/biomolther.2009.17.2.133
DO - 10.4062/biomolther.2009.17.2.133
M3 - Article
AN - SCOPUS:69549118369
VL - 17
SP - 133
EP - 137
JO - Biomolecules and Therapeutics
JF - Biomolecules and Therapeutics
SN - 1976-9148
IS - 2
ER -