First add-on perampanel for focal-onset seizures: An open-label, prospective study

Ji Hyun Kim, Dong Wook Kim, Sang Kun Lee, Dae Won Seo, Ji Woong Lee, Hae Joon Park, Sang Ahm Lee

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Objectives: This study aimed to determine the efficacy and safety of perampanel added to monotherapy in patients with focal-onset seizures, with or without secondarily generalized tonic-clonic seizures. Materials & Methods: In this multicentre, open-label trial, enrolled patients were treated with perampanel monotherapy. During a 12-week titration period, perampanel was incrementally increased by 2 mg/d over ≥2-week intervals. Patients then entered a 24-week maintenance period. The primary objective was to investigate the 50% responder rate in total seizure frequency, with 75% and 100% responder rates as secondary objectives. Treatment-emergent adverse events (TEAEs) and adverse drug reactions were recorded. A post hoc analysis was performed to investigate the effect of titration speed and different concomitant AEDs on the efficacy and safety of perampanel. Results: Of the 85 patients analysed, seizure reductions of 50%, 75% and 100% were observed in 80.0% (95% confidence interval [CI]: 69.9-87.9), 71.8% (95% CI: 61.0-81.0) and 47.1% (95% CI: 36.1-58.2) during the maintenance period, respectively. The 50%, 75% and 100% response rates in patients with secondarily generalized tonic-clonic seizures were 87.5% (95% CI: 61.7-98.5), 87.5% (95% CI: 61.7-98.5) and 75.0% (95% CI: 47.6-92.7), respectively. The most common TEAEs were dizziness (50.0%), somnolence (9.8%) and headache (8.8%). The efficacy outcomes and safety profile of perampanel were more favourable with slow titration and relatively consistent when stratified by concomitant AEDs. Conclusions: Perampanel was effective and well tolerated as a first add-on to monotherapy in patients with focal-onset seizures, with or without secondarily generalized seizures.

    Original languageEnglish
    Pages (from-to)132-140
    Number of pages9
    JournalActa Neurologica Scandinavica
    Volume141
    Issue number2
    DOIs
    Publication statusPublished - 2020 Feb 1

    Keywords

    • AMPA receptor
    • drug resistance
    • epilepsy
    • focal seizures
    • generalised tonic-clonic seizures

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

    Fingerprint

    Dive into the research topics of 'First add-on perampanel for focal-onset seizures: An open-label, prospective study'. Together they form a unique fingerprint.

    Cite this