First-generation versus second-generation drug-eluting stents in coronary chronic total occlusions: Two-year results of a multicenter registry

Jong Hwa Ahn, Jeong Hoon Yang, Cheol Woong Yu, Je Sang Kim, Hyun Jong Lee, Rak Kyeong Choi, Tae Hoon Kim, Ho Joon Jang, Young Jin Choi, Young Moo Roh, Won Heum Shim, Young Bin Song, Joo Yong Hahn, Jin Ho Choi, Sang Hoon Lee, Hyeon Cheol Gwon, Seung Hyuk Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Limited data are available regarding the long-term clinical outcomes of second-generation drug-eluting stents (DES) versus first-generation DES in patients with coronary chronic total occlusion (CTO) who undergo percutaneous coronary intervention (PCI). The aim of this study was to compare the clinical outcomes of second-generation DES with those of firstgeneration DES for the treatment of CTO. Methods and Results Between March 2003 and February 2012, 1,006 consecutive patients with CTO who underwent successful PCI using either first-generation DES (n = 557) or second-generation DES (n = 449) were enrolled in a multicenter, observational registry. Propensity-score matching was also performed. The primary outcome was cardiac death over a 2-year follow-up period. No significant differences were observed between the two groups regarding the incidence of cardiac death (first-generation DES versus second-generation DES; 2.5% vs 2.0%; hazard ratio [HR]: 0.86; 95% confidence interval [CI]: 0.37 to 1.98; p = 0.72) or major adverse cardiac events (MACE, 11.8% vs 11.4%; HR: 1.00; 95% CI: 0.67 to 1.50; p = 0.99). After propensity score matching, the incidences of cardiac death (HR: 0.86; 95% CI: 0.35 to 2.06; p = 0.86) and MACE (HR: 0.93; 95% CI: 0.63 to 1.37; p = 0.71) were still similar in both groups. Furthermore, no significant differences were observed between sirolimus-eluting, paclitaxel-eluting, zotarolimus-eluting, and everolimus-eluting stents regarding the incidence of cardiac death or MACE. Conclusion This study shows that the efficacy of second-generation DES is comparable to that of firstgeneration DES for treatment of CTO over 2 years of follow-up.

Original languageEnglish
Article numbere0157549
JournalPloS one
Volume11
Issue number6
DOIs
Publication statusPublished - 2016 Jun

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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