Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.
|Number of pages||3|
|Publication status||Published - 2011 Oct 7|
ASJC Scopus subject areas
- Chemical Engineering(all)