Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

Aiichiro Nagaki, Keita Imai, Heejin Kim, Jun Ichi Yoshida

Research output: Contribution to journalArticle

23 Citations (Scopus)


Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.

Original languageEnglish
Pages (from-to)758-760
Number of pages3
JournalRSC Advances
Issue number5
Publication statusPublished - 2011 Oct 7


ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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