Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

Dong Nam Lee; Eunjin Kim; Jae Hong Lee; Jong Seung Kim; Chulhun Kang; Jong In Hong

doi:10.1039/c6cc07483a

Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

Dong Nam Lee, Eunjin Kim, Jae Hong Lee, Jong Seung Kim, Chulhun Kang, Jong In Hong

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φ_f = 6.50 × 10³ M⁻¹ cm⁻¹) at long wavelengths (maximum emission wavelength, λ_max = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.

Original language	English
Pages (from-to)	13487-13490
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	92
DOIs	https://doi.org/10.1039/c6cc07483a
Publication status	Published - 2016

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Flavin-mediated photo-oxidation for the detection of mitochondrial flavins",

abstract = "We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 103 M−1 cm−1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.",

author = "Lee, {Dong Nam} and Eunjin Kim and Lee, {Jae Hong} and Kim, {Jong Seung} and Chulhun Kang and Hong, {Jong In}",

note = "Funding Information: This work was supported by the NRF grant (No. 2015R1A2A1A15055347, 2014R1A2A1A11052325, and 2009-0081566) funded by the MSIP. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6cc07483a",

language = "English",

volume = "52",

pages = "13487--13490",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "92",

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TY - JOUR

T1 - Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

AU - Lee, Dong Nam

AU - Kim, Eunjin

AU - Lee, Jae Hong

AU - Kim, Jong Seung

AU - Kang, Chulhun

AU - Hong, Jong In

N1 - Funding Information: This work was supported by the NRF grant (No. 2015R1A2A1A15055347, 2014R1A2A1A11052325, and 2009-0081566) funded by the MSIP. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 103 M−1 cm−1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.

AB - We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 103 M−1 cm−1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.

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U2 - 10.1039/c6cc07483a

DO - 10.1039/c6cc07483a

M3 - Article

C2 - 27801440

AN - SCOPUS:84994894121

SN - 1359-7345

VL - 52

SP - 13487

EP - 13490

JO - Chemical Communications

JF - Chemical Communications

IS - 92

ER -

Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

Abstract

ASJC Scopus subject areas

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