Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

Dong Nam Lee, Eunjin Kim, Jae Hong Lee, Jong Seung Kim, Chulhun Kang, Jong In Hong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 103 M−1 cm−1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.

Original languageEnglish
Pages (from-to)13487-13490
Number of pages4
JournalChemical Communications
Volume52
Issue number92
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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