Flexible and implantable capacitive microelectrode for bio-potential acquisition

Seung Min Lee, Hang Jin Byeon, Bong Hoon Kim, Jungyup Lee, Ji Yoon Jeong, Joong Hoon Lee, Jin Hee Moon, Cheolsoo Park, Hyuk Choi, Sang Hoon Lee, Kwang Ho Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Electrodes should be adhered onto the body steadily under motion, and implanted stably into the tissue without any damages while maintaining conformal contact. Although most electrodes are fabricated with biocompatible materials, they should be shielded from tissues to prevent mechanical delamination from the device itself and to avoid adverse effects such as irritation, allergic reactions, or inflammation. Herein, we demonstrate a simple process for the development of a flexible and implantable capacitive electrode based on a minimal incision accessible design with polyimide (PI) and Gold/Titanium (Au/Ti) layers and completely encapsulated in a polydimethylsiloxane (PDMS) substrate. Electrodes of three different sizes (recording site diameters of 1.8 mm, 2.8 mm, and 3.8 mm, respectively) were fabricated and examined in this work. Electrocardiography (ECG) was recorded in the dorsal area of the rat for 4 weeks for biological signal checkup. We obtained stable and robust ECG signals owing to the intrinsic property of capacitive coupling, with almost no leakage current compared to the direct contact electrode for the applied current over the range of 0 to 10 mA. These results indicate that our electrode can be used to detect bio-signals effectively in the long term, and can play a role in electroceuticals in the near future.

Original languageEnglish
Pages (from-to)153-163
Number of pages11
JournalBiochip Journal
Volume11
Issue number2
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

Microelectrodes
Electrodes
Electrocardiography
Implanted Electrodes
Tissue
Biocompatible Materials
Titanium
Gold
Polydimethylsiloxane
Hypersensitivity
Delamination
Polyimides
Biomaterials
Leakage currents
Rats
Inflammation
Equipment and Supplies
Substrates

Keywords

  • Bio-potential
  • Capacitive Coupling
  • Electrocardiography (ECG)
  • Electrode: Polydimethylsiloxane (PDMS)
  • Gold/Titanium (Au/Ti)

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Lee, S. M., Byeon, H. J., Kim, B. H., Lee, J., Jeong, J. Y., Lee, J. H., ... Lee, K. H. (2017). Flexible and implantable capacitive microelectrode for bio-potential acquisition. Biochip Journal, 11(2), 153-163. https://doi.org/10.1007/s13206-017-1304-y

Flexible and implantable capacitive microelectrode for bio-potential acquisition. / Lee, Seung Min; Byeon, Hang Jin; Kim, Bong Hoon; Lee, Jungyup; Jeong, Ji Yoon; Lee, Joong Hoon; Moon, Jin Hee; Park, Cheolsoo; Choi, Hyuk; Lee, Sang Hoon; Lee, Kwang Ho.

In: Biochip Journal, Vol. 11, No. 2, 01.06.2017, p. 153-163.

Research output: Contribution to journalArticle

Lee, SM, Byeon, HJ, Kim, BH, Lee, J, Jeong, JY, Lee, JH, Moon, JH, Park, C, Choi, H, Lee, SH & Lee, KH 2017, 'Flexible and implantable capacitive microelectrode for bio-potential acquisition', Biochip Journal, vol. 11, no. 2, pp. 153-163. https://doi.org/10.1007/s13206-017-1304-y
Lee, Seung Min ; Byeon, Hang Jin ; Kim, Bong Hoon ; Lee, Jungyup ; Jeong, Ji Yoon ; Lee, Joong Hoon ; Moon, Jin Hee ; Park, Cheolsoo ; Choi, Hyuk ; Lee, Sang Hoon ; Lee, Kwang Ho. / Flexible and implantable capacitive microelectrode for bio-potential acquisition. In: Biochip Journal. 2017 ; Vol. 11, No. 2. pp. 153-163.
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