Flow lithography in ultraviolet-curable polydimethylsiloxane microfluidic chips

Junbeom Kim, Heseong An, Yoojin Seo, Youngmee Jung, Jong Suk Lee, Nakwon Choi, Ki Wan Bong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Flow Lithography (FL) is the technique used for the synthesis of hydrogel microparticles with various complex shapes and distinct chemical compositions by combining microfluidics with photolithography. Although polydimethylsiloxane (PDMS) has been used most widely as almost the sole material for FL, PDMS microfluidic chips have limitations: (1) undesired shrinkage due to the thermal expansion of masters used for replica molding and (2) interfacial delamination between two thermally cured PDMS layers. Here, we propose the utilization of ultraviolet (UV)-curable PDMS (X-34-4184) for FL as an excellent alternative material of the conventional PDMS. Our proposed utilization of the UV-curable PDMS offers three key advantages, observed in our study: (1) UV-curable PDMS exhibited almost the same oxygen permeability as the conventional PDMS. (2) The almost complete absence of shrinkage facilitated the fabrication of more precise reverse duplication of microstructures. (3) UV-cured PDMS microfluidic chips were capable of much stronger interfacial bonding so that the burst pressure increased to ~0.9 MPa. Owing to these benefits, we demonstrated a substantial improvement of productivity in synthesizing polyethylene glycol diacrylate microparticles via stop flow lithography, by applying a flow time (40 ms) an order of magnitude shorter. Our results suggest that UV-cured PDMS chips can be used as a general platform for various types of flow lithography and also be employed readily in other applications where very precise replication of structures on micro- or submicrometer scales and/or strong interfacial bonding are desirable.

Original languageEnglish
Article number024120
JournalBiomicrofluidics
Volume11
Issue number2
DOIs
Publication statusPublished - 2017 Mar 1

Fingerprint

Microfluidics
Polydimethylsiloxane
Lithography
lithography
chips
microparticles
shrinkage
photolithography
productivity
replicas
baysilon
micrometers
glycols
polyethylenes
thermal expansion
bursts
permeability
chemical composition
platforms
Hydrogel

ASJC Scopus subject areas

  • Materials Science(all)
  • Molecular Biology
  • Genetics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Flow lithography in ultraviolet-curable polydimethylsiloxane microfluidic chips. / Kim, Junbeom; An, Heseong; Seo, Yoojin; Jung, Youngmee; Lee, Jong Suk; Choi, Nakwon; Bong, Ki Wan.

In: Biomicrofluidics, Vol. 11, No. 2, 024120, 01.03.2017.

Research output: Contribution to journalArticle

Kim, Junbeom ; An, Heseong ; Seo, Yoojin ; Jung, Youngmee ; Lee, Jong Suk ; Choi, Nakwon ; Bong, Ki Wan. / Flow lithography in ultraviolet-curable polydimethylsiloxane microfluidic chips. In: Biomicrofluidics. 2017 ; Vol. 11, No. 2.
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