Fluorescent bioimaging of pH: From design to applications

Ji Ting Hou, Wen Xiu Ren, Kun Li, Jinho Seo, Amit Sharma, Xiao Qi Yu, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

354 Citations (Scopus)


Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable. This review highlights the recent trends in the development of fluorescent materials as essential tools for tracing pH variations in the biological processes of diverse living systems.

Original languageEnglish
Pages (from-to)2076-2090
Number of pages15
JournalChemical Society Reviews
Issue number8
Publication statusPublished - 2017 Apr 21

ASJC Scopus subject areas

  • Chemistry(all)


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