TY - JOUR
T1 - Fluorescent bioimaging of pH
T2 - From design to applications
AU - Hou, Ji Ting
AU - Ren, Wen Xiu
AU - Li, Kun
AU - Seo, Jinho
AU - Sharma, Amit
AU - Yu, Xiao Qi
AU - Kim, Jong Seung
N1 - Funding Information:
This work was supported by the Ministry of Science, ICT; Future Planning (MSIP) of Korea (no. 2009-0081566 for JSK); the National Program on Key Basic Research Project of China (973 Program, 2013CB328905); and the National Natural Science Foundation of China (no. 21232005 and 21572147).
Publisher Copyright:
© The Royal Society of Chemistry 2017.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2017/4/21
Y1 - 2017/4/21
N2 - Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable. This review highlights the recent trends in the development of fluorescent materials as essential tools for tracing pH variations in the biological processes of diverse living systems.
AB - Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable. This review highlights the recent trends in the development of fluorescent materials as essential tools for tracing pH variations in the biological processes of diverse living systems.
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U2 - 10.1039/c6cs00719h
DO - 10.1039/c6cs00719h
M3 - Review article
C2 - 28317979
AN - SCOPUS:85018483309
SN - 0306-0012
VL - 46
SP - 2076
EP - 2090
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 8
ER -