Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution

Ja Hyung Kim, Hyun Jung Kim, Sang Hoon Kim, Jae Hong Lee, Jung Ho Do, Hae Jo Kim, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

A coumarin-based dithiane (1) was synthesized for the selective detection of Hg2+ with respect to dual chromo- and fluorogenic changing events in an aqueous solution by the mercury-promoted transformation of a dithiane group into an aldehyde functional unit. The Hg2+-selective response of the chemodosimeter was clearly observed in aqueous buffer as well as in human blood plasma medium.

Original languageEnglish
Pages (from-to)5958-5961
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number43
DOIs
Publication statusPublished - 2009 Oct 28

Keywords

  • Chromogenic
  • Coumarin
  • Fluorogenic
  • Mercury ion

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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