Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media

Sumin Lee, Jae Hong Lee, Tuhin Pradhan, Chang Su Lim, Bong-Rae Cho, Sankarprasad Bhuniya, Sungtae Kim, Jong Seung Kim

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.

Original languageEnglish
Pages (from-to)1489-1493
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume160
Issue number1
DOIs
Publication statusPublished - 2011 Dec 15

Keywords

  • Cell imaging
  • DFT calculations
  • Fluorescent sensor
  • Zinc

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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