Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media

Sumin Lee, Jae Hong Lee, Tuhin Pradhan, Chang Su Lim, Bong-Rae Cho, Sankarprasad Bhuniya, Sungtae Kim, Jong Seung Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.

Original languageEnglish
Pages (from-to)1489-1493
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume160
Issue number1
DOIs
Publication statusPublished - 2011 Dec 15

Fingerprint

Naphthalimides
Bearings (structural)
sensors
Sensors
Chelation
carboxylates
affinity
Microscopic examination
permeability
Metals
Ions
aqueous solutions
microscopy
Imaging techniques
Water
probes
sensitivity
cells
metals
water

Keywords

  • Cell imaging
  • DFT calculations
  • Fluorescent sensor
  • Zinc

ASJC Scopus subject areas

  • Instrumentation
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media. / Lee, Sumin; Lee, Jae Hong; Pradhan, Tuhin; Lim, Chang Su; Cho, Bong-Rae; Bhuniya, Sankarprasad; Kim, Sungtae; Kim, Jong Seung.

In: Sensors and Actuators, B: Chemical, Vol. 160, No. 1, 15.12.2011, p. 1489-1493.

Research output: Contribution to journalArticle

Lee, Sumin ; Lee, Jae Hong ; Pradhan, Tuhin ; Lim, Chang Su ; Cho, Bong-Rae ; Bhuniya, Sankarprasad ; Kim, Sungtae ; Kim, Jong Seung. / Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media. In: Sensors and Actuators, B: Chemical. 2011 ; Vol. 160, No. 1. pp. 1489-1493.
@article{55fda8b307534b0ba4790fc19d71b2c6,
title = "Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media",
abstract = "A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100{\%} aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.",
keywords = "Cell imaging, DFT calculations, Fluorescent sensor, Zinc",
author = "Sumin Lee and Lee, {Jae Hong} and Tuhin Pradhan and Lim, {Chang Su} and Bong-Rae Cho and Sankarprasad Bhuniya and Sungtae Kim and Kim, {Jong Seung}",
year = "2011",
month = "12",
day = "15",
doi = "10.1016/j.snb.2011.07.065",
language = "English",
volume = "160",
pages = "1489--1493",
journal = "Sensors and Actuators, B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media

AU - Lee, Sumin

AU - Lee, Jae Hong

AU - Pradhan, Tuhin

AU - Lim, Chang Su

AU - Cho, Bong-Rae

AU - Bhuniya, Sankarprasad

AU - Kim, Sungtae

AU - Kim, Jong Seung

PY - 2011/12/15

Y1 - 2011/12/15

N2 - A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.

AB - A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.

KW - Cell imaging

KW - DFT calculations

KW - Fluorescent sensor

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=84860391447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860391447&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2011.07.065

DO - 10.1016/j.snb.2011.07.065

M3 - Article

VL - 160

SP - 1489

EP - 1493

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

SN - 0925-4005

IS - 1

ER -