Several researchers conducted studies to demonstrate the use of fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens. They demonstrated that fluorescent chemodosimeters had emerged as as a research area of significant importance due to their potential in detecting heavy metal ions in solution and biospecimens. Chemodosimeters were used to detect an analyte through a highly selective and irreversible chemical reaction between the dosimeter molecule and the target analyte. This led to an observable signal that had an accumulative effect and was directly related to the concentration of the analyte. The chemodosimeter also provided signaling changes in absorption wavelength and color that were widely used as detection events, as they required only the use of cost-effective equipment or no equipment in some cases.
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