FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans

Matthew D. Nelson, Kun He Lee, Matthew A. Churgin, Andrew J. Hill, Cheryl Van Buskirk, Christopher Fang-Yen, David M. Raizen

Research output: Contribution to journalArticle

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Abstract

Among the most important decisions an animal makes is whether to engage in active movement and feeding behavior or to become quiescent. The molecular signaling mechanisms underlying this decision remain largely unknown. The nematode Caenorhabditis elegans displays sleep-like quiescence following exposures that result in cellular stress [1]. The neurosecretory ALA neuron is required for this stress-induced recovery quiescence [1], but the mechanisms by which ALA induces quiescence have been unknown. We report here that quiescence induced by heat stress requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene. Optogenetic activation of ALA reduces feeding and locomotion in a FLP-13-dependent manner. Overexpression of flp-13 is sufficient to induce quiescent behavior during normally active periods. We have here identified a major biological role for FMRFamide-like neuropeptides in nematodes, and we suggest that they may function in a similar capacity in other organisms.

Original languageEnglish
Pages (from-to)2406-2410
Number of pages5
JournalCurrent Biology
Volume24
Issue number20
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

FMRFamide
Caenorhabditis elegans
neuropeptides
Neuropeptides
heat stress
Hot Temperature
Optogenetics
Nematoda
Feeding Behavior
Locomotion
sleep
feeding behavior
locomotion
Sleep
neurons
Depolarization
Neurons
organisms
Animals
Genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nelson, M. D., Lee, K. H., Churgin, M. A., Hill, A. J., Van Buskirk, C., Fang-Yen, C., & Raizen, D. M. (2014). FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans. Current Biology, 24(20), 2406-2410. https://doi.org/10.1016/j.cub.2014.08.037

FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans. / Nelson, Matthew D.; Lee, Kun He; Churgin, Matthew A.; Hill, Andrew J.; Van Buskirk, Cheryl; Fang-Yen, Christopher; Raizen, David M.

In: Current Biology, Vol. 24, No. 20, 01.01.2014, p. 2406-2410.

Research output: Contribution to journalArticle

Nelson, MD, Lee, KH, Churgin, MA, Hill, AJ, Van Buskirk, C, Fang-Yen, C & Raizen, DM 2014, 'FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans', Current Biology, vol. 24, no. 20, pp. 2406-2410. https://doi.org/10.1016/j.cub.2014.08.037
Nelson MD, Lee KH, Churgin MA, Hill AJ, Van Buskirk C, Fang-Yen C et al. FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans. Current Biology. 2014 Jan 1;24(20):2406-2410. https://doi.org/10.1016/j.cub.2014.08.037
Nelson, Matthew D. ; Lee, Kun He ; Churgin, Matthew A. ; Hill, Andrew J. ; Van Buskirk, Cheryl ; Fang-Yen, Christopher ; Raizen, David M. / FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans. In: Current Biology. 2014 ; Vol. 24, No. 20. pp. 2406-2410.
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