fMRI adaptation between action observation and action execution reveals cortical areas with mirror neuron properties in human BA 44/45

Stephan de la Rosa, Frieder L. Schillinger, Heinrich Bulthoff, Johannes Schultz, Kamil Uludag

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mirror neurons (MNs) are considered to be the supporting neural mechanism for action understanding. MNs have been identified in monkey’s area F5. The identification of MNs in the human homolog of monkeys’ area F5 Broadmann Area 44/45 (BA 44/45) has been proven methodologically difficult. Cross-modal functional MRI (fMRI) adaptation studies supporting the existence of MNs restricted their analysis to a priori candidate regions, whereas studies that failed to find evidence used non-object-directed (NDA) actions. We tackled these limitations by using object-directed actions (ODAs) differing only in terms of their object directedness in combination with a cross-modal adaptation paradigm and a whole-brain analysis. Additionally, we tested voxels’ blood oxygenation level-dependent (BOLD) response patterns for several properties previously reported as typical MN response properties. Our results revealed 52 voxels in left inferior frontal gyrus (IFG; particularly BA 44/45), which respond to both motor and visual stimulation and exhibit cross-modal adaptation between the execution and observation of the same action. These results demonstrate that part of human IFG, specifically BA 44/45, has BOLD response characteristics very similar to monkey’s area F5.

Original languageEnglish
Article number78
JournalFrontiers in Human Neuroscience
Volume10
Issue numberFEB2016
DOIs
Publication statusPublished - 2016 Feb 29
Externally publishedYes

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Keywords

  • Action recognition
  • Adaptation
  • BA 44
  • BA 45
  • fMRI
  • Mirror neurons
  • Object-directed actions
  • Repetition suppression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

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