Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity

Byoung-Kyong Min, Alexander Bystritsky, Kwang Ik Jung, Krisztina Fischer, Yongzhi Zhang, Lee So Maeng, Sang In Park, Yong An Chung, Ferenc A. Jolesz, Seung Schik Yoo

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Background: Epilepsy is a common neurological disorder, which is attributed to uncontrollable abnormal hyper-excitability of neurons. We investigated the feasibility of using low-intensity, pulsed radiation of focused ultrasound (FUS) to non-invasively suppress epileptic activity in an animal model (rat), which was induced by the intraperitonial injection of pentylenetetrazol (PTZ).Results: After the onset of induced seizures, FUS was transcranially administered to the brain twice for three minutes each while undergoing electroencephalographic (EEG) monitoring. An air-backed, spherical segment ultrasound transducer (diameter: 6 cm; radius-of-curvature: 7 cm) operating at a fundamental frequency of 690 KHz was used to deliver a train of 0.5 msec-long pulses of sonication at a repetitive rate of 100 Hz to the thalamic areas of the brain. The acoustic intensity (130 mW/cm2) used in the experiment was sufficiently within the range of safety guidelines for the clinical ultrasound imaging. The occurrence of epileptic EEG bursts from epilepsy-induced rats significantly decreased after sonication when it was compared to the pre-sonication epileptic state. The PTZ-induced control group that did not receive any sonication showed a sustained number of epileptic EEG signal bursts. The animals that underwent sonication also showed less severe epileptic behavior, as assessed by the Racine score. Histological analysis confirmed that the sonication did not cause any damage to the brain tissue.Conclusions: These results revealed that low-intensity, pulsed FUS sonication suppressed the number of epileptic signal bursts using acute epilepsy model in animal. Due to its non-invasiveness and spatial selectivity, FUS may offer new perspectives for a possible non-invasive treatment of epilepsy.

Original languageEnglish
Article number23
JournalBMC Neuroscience
Volume12
DOIs
Publication statusPublished - 2011 Mar 6
Externally publishedYes

Fingerprint

Sonication
Epilepsy
Pentylenetetrazole
Brain
Animal Models
Nervous System Diseases
Transducers
Acoustics
Ultrasonography
Seizures
Air
Guidelines
Safety
Neurons
Control Groups
Injections

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)

Cite this

Min, B-K., Bystritsky, A., Jung, K. I., Fischer, K., Zhang, Y., Maeng, L. S., ... Yoo, S. S. (2011). Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity. BMC Neuroscience, 12, [23]. https://doi.org/10.1186/1471-2202-12-23

Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity. / Min, Byoung-Kyong; Bystritsky, Alexander; Jung, Kwang Ik; Fischer, Krisztina; Zhang, Yongzhi; Maeng, Lee So; In Park, Sang; Chung, Yong An; Jolesz, Ferenc A.; Yoo, Seung Schik.

In: BMC Neuroscience, Vol. 12, 23, 06.03.2011.

Research output: Contribution to journalArticle

Min, B-K, Bystritsky, A, Jung, KI, Fischer, K, Zhang, Y, Maeng, LS, In Park, S, Chung, YA, Jolesz, FA & Yoo, SS 2011, 'Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity', BMC Neuroscience, vol. 12, 23. https://doi.org/10.1186/1471-2202-12-23
Min, Byoung-Kyong ; Bystritsky, Alexander ; Jung, Kwang Ik ; Fischer, Krisztina ; Zhang, Yongzhi ; Maeng, Lee So ; In Park, Sang ; Chung, Yong An ; Jolesz, Ferenc A. ; Yoo, Seung Schik. / Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity. In: BMC Neuroscience. 2011 ; Vol. 12.
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