Focused ultrasound modulates region-specific brain activity

Seung Schik Yoo, Alexander Bystritsky, Jong-Hwan Lee, Yongzhi Zhang, Krisztina Fischer, Byoung-Kyong Min, Nathan J. McDannold, Alvaro Pascual-Leone, Ferenc A. Jolesz

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the animal's somatomotor and visual areas, as guided by anatomical and functional information from magnetic resonance imaging (MRI). The temporary alterations in the brain function affected by the sonication were characterized by both electrophysiological recordings and functional brain mapping achieved through the use of functional MRI (fMRI). The modulatory effects were bimodal, whereby the brain activity could either be stimulated or selectively suppressed. Histological analysis of the excised brain tissue after the sonication demonstrated that the FUS did not elicit any tissue damages. Unlike transcranial magnetic stimulation, FUS can be applied to deep structures in the brain with greater spatial precision. Transient modulation of brain function using image-guided and anatomically-targeted FUS would enable the investigation of functional connectivity between brain regions and will eventually lead to a better understanding of localized brain functions. It is anticipated that the use of this technology will have an impact on brain research and may offer novel therapeutic interventions in various neurological conditions and psychiatric disorders.

Original languageEnglish
Pages (from-to)1267-1275
Number of pages9
JournalNeuroImage
Volume56
Issue number3
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

Brain
Sonication
Magnetic Resonance Imaging
Brain Mapping
Transcranial Magnetic Stimulation
Motor Cortex
Acoustics
Psychiatry
Rabbits
Technology
Research
Therapeutics

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Yoo, S. S., Bystritsky, A., Lee, J-H., Zhang, Y., Fischer, K., Min, B-K., ... Jolesz, F. A. (2011). Focused ultrasound modulates region-specific brain activity. NeuroImage, 56(3), 1267-1275. https://doi.org/10.1016/j.neuroimage.2011.02.058

Focused ultrasound modulates region-specific brain activity. / Yoo, Seung Schik; Bystritsky, Alexander; Lee, Jong-Hwan; Zhang, Yongzhi; Fischer, Krisztina; Min, Byoung-Kyong; McDannold, Nathan J.; Pascual-Leone, Alvaro; Jolesz, Ferenc A.

In: NeuroImage, Vol. 56, No. 3, 01.06.2011, p. 1267-1275.

Research output: Contribution to journalArticle

Yoo, SS, Bystritsky, A, Lee, J-H, Zhang, Y, Fischer, K, Min, B-K, McDannold, NJ, Pascual-Leone, A & Jolesz, FA 2011, 'Focused ultrasound modulates region-specific brain activity', NeuroImage, vol. 56, no. 3, pp. 1267-1275. https://doi.org/10.1016/j.neuroimage.2011.02.058
Yoo, Seung Schik ; Bystritsky, Alexander ; Lee, Jong-Hwan ; Zhang, Yongzhi ; Fischer, Krisztina ; Min, Byoung-Kyong ; McDannold, Nathan J. ; Pascual-Leone, Alvaro ; Jolesz, Ferenc A. / Focused ultrasound modulates region-specific brain activity. In: NeuroImage. 2011 ; Vol. 56, No. 3. pp. 1267-1275.
@article{071095f1ece545d1bb00316e418d48b2,
title = "Focused ultrasound modulates region-specific brain activity",
abstract = "We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the animal's somatomotor and visual areas, as guided by anatomical and functional information from magnetic resonance imaging (MRI). The temporary alterations in the brain function affected by the sonication were characterized by both electrophysiological recordings and functional brain mapping achieved through the use of functional MRI (fMRI). The modulatory effects were bimodal, whereby the brain activity could either be stimulated or selectively suppressed. Histological analysis of the excised brain tissue after the sonication demonstrated that the FUS did not elicit any tissue damages. Unlike transcranial magnetic stimulation, FUS can be applied to deep structures in the brain with greater spatial precision. Transient modulation of brain function using image-guided and anatomically-targeted FUS would enable the investigation of functional connectivity between brain regions and will eventually lead to a better understanding of localized brain functions. It is anticipated that the use of this technology will have an impact on brain research and may offer novel therapeutic interventions in various neurological conditions and psychiatric disorders.",
author = "Yoo, {Seung Schik} and Alexander Bystritsky and Jong-Hwan Lee and Yongzhi Zhang and Krisztina Fischer and Byoung-Kyong Min and McDannold, {Nathan J.} and Alvaro Pascual-Leone and Jolesz, {Ferenc A.}",
year = "2011",
month = "6",
day = "1",
doi = "10.1016/j.neuroimage.2011.02.058",
language = "English",
volume = "56",
pages = "1267--1275",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Focused ultrasound modulates region-specific brain activity

AU - Yoo, Seung Schik

AU - Bystritsky, Alexander

AU - Lee, Jong-Hwan

AU - Zhang, Yongzhi

AU - Fischer, Krisztina

AU - Min, Byoung-Kyong

AU - McDannold, Nathan J.

AU - Pascual-Leone, Alvaro

AU - Jolesz, Ferenc A.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the animal's somatomotor and visual areas, as guided by anatomical and functional information from magnetic resonance imaging (MRI). The temporary alterations in the brain function affected by the sonication were characterized by both electrophysiological recordings and functional brain mapping achieved through the use of functional MRI (fMRI). The modulatory effects were bimodal, whereby the brain activity could either be stimulated or selectively suppressed. Histological analysis of the excised brain tissue after the sonication demonstrated that the FUS did not elicit any tissue damages. Unlike transcranial magnetic stimulation, FUS can be applied to deep structures in the brain with greater spatial precision. Transient modulation of brain function using image-guided and anatomically-targeted FUS would enable the investigation of functional connectivity between brain regions and will eventually lead to a better understanding of localized brain functions. It is anticipated that the use of this technology will have an impact on brain research and may offer novel therapeutic interventions in various neurological conditions and psychiatric disorders.

AB - We demonstrated the in vivo feasibility of using focused ultrasound (FUS) to transiently modulate (through either stimulation or suppression) the function of regional brain tissue in rabbits. FUS was delivered in a train of pulses at low acoustic energy, far below the cavitation threshold, to the animal's somatomotor and visual areas, as guided by anatomical and functional information from magnetic resonance imaging (MRI). The temporary alterations in the brain function affected by the sonication were characterized by both electrophysiological recordings and functional brain mapping achieved through the use of functional MRI (fMRI). The modulatory effects were bimodal, whereby the brain activity could either be stimulated or selectively suppressed. Histological analysis of the excised brain tissue after the sonication demonstrated that the FUS did not elicit any tissue damages. Unlike transcranial magnetic stimulation, FUS can be applied to deep structures in the brain with greater spatial precision. Transient modulation of brain function using image-guided and anatomically-targeted FUS would enable the investigation of functional connectivity between brain regions and will eventually lead to a better understanding of localized brain functions. It is anticipated that the use of this technology will have an impact on brain research and may offer novel therapeutic interventions in various neurological conditions and psychiatric disorders.

UR - http://www.scopus.com/inward/record.url?scp=79955482271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955482271&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2011.02.058

DO - 10.1016/j.neuroimage.2011.02.058

M3 - Article

C2 - 21354315

AN - SCOPUS:79955482271

VL - 56

SP - 1267

EP - 1275

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3

ER -