Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy

Hyounkoo Han, Doyeon Kim, Yongho Jang, Minkyu Seo, Kwangmeyung Kim, Jong Bum Lee, Hyuncheol Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Nanotechnology-based combination therapies, especially chemo-gene therapy, have been spotlighted as promising alternatives for cancer therapy. However, only a small amount of systemically administered nanomedicines reach the tumor site by the enhanced permeability and retention (EPR) effect, resulting in the limited therapeutic efficacy. Furthermore, the design of ideal drug delivery system for chemo-gene therapy has been impeded by the chemical and physical differences between nucleic acids and chemotherapeutics. Herein, we report a precisely designed nanocomplex which exhibits a focused ultrasound (FU)-responsive release and enhanced accumulation of released therapeutics to tumor site. After the nanocomplex composed of siRNA nanoparticles (siRNA-NP) and chemotherapeutics-loaded microbubbles was systemically injected, the nanocomplex was collapsed around the tumor tissue by FU exposure, and both siRNA-NP and chemotherapeutics were penetrated the dense extracellular matrix (ECM) of tumor site, leading to the enhanced chemo-gene therapeutic efficacy. The two-in-one nanocomplex is expected as a promising platform for combination therapy that can enhance the therapeutic efficiency of combination drugs at the cell and/or tissue levels with high drug loading ratio.

Original languageEnglish
Pages (from-to)346-356
Number of pages11
JournalJournal of Controlled Release
Volume322
DOIs
Publication statusPublished - 2020 Jun 10

Keywords

  • Chemo-gene therapy
  • Focused ultrasound
  • Mechanical effect
  • Nanocomplex
  • Sonoporation effect

ASJC Scopus subject areas

  • Pharmaceutical Science

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