Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery

Kui Kun Yang, Ming Kong, Ya Nan Wei, Ya Liu, Xiao Jie Cheng, Jing Li, Hyun Jin Park, Xi Guang Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In this study, a folate-modified-chitosan-coated liposome (FCCL) was prepared for tumor-targeted drug delivery. The folate-chitosan conjugates were characterized using 1H NMR and infrared spectrum analysis. The properties of folate-chitosan-coated liposomes (FCCLs) were studied and compared with those of traditional liposomes and chitosan-coated liposomes (CCLs). FCCLs were spherical in shape with a classic core-shell structure. Compared with conventional liposomes, FCCLs had larger size (average diameter: 182.0 nm), higher zeta potential (10.1 mV), prolonged drug release behaviors (55.76 % after 24 h), and better physical stability when stored at 25 C, all similar to the properties of CCLs. With fluorescein as a model drug, fluorescein-loaded liposomes, CCLs, and FCCLs were prepared and their tumor targeting ability was evaluated according to the in vitro cellular uptake of fluorescein loaded nanoparticles by MCF-7 and HUVEC cells. Results demonstrated that FCCLs had a significant higher uptake by folate receptor positive cells (MCF-7) as compared to traditional liposomes and CCLs, which indicated that the FCCLs were promising nano-carriers for tumor-targeted drug delivery.

Original languageEnglish
Pages (from-to)1717-1728
Number of pages12
JournalJournal of Materials Science
Volume48
Issue number4
DOIs
Publication statusPublished - 2013 Feb

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Yang, K. K., Kong, M., Wei, Y. N., Liu, Y., Cheng, X. J., Li, J., Park, H. J., & Chen, X. G. (2013). Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery. Journal of Materials Science, 48(4), 1717-1728. https://doi.org/10.1007/s10853-012-6930-0