Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery

Kui Kun Yang, Ming Kong, Ya Nan Wei, Ya Liu, Xiao Jie Cheng, Jing Li, Hyun Jin Park, Xi Guang Chen

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In this study, a folate-modified-chitosan-coated liposome (FCCL) was prepared for tumor-targeted drug delivery. The folate-chitosan conjugates were characterized using 1H NMR and infrared spectrum analysis. The properties of folate-chitosan-coated liposomes (FCCLs) were studied and compared with those of traditional liposomes and chitosan-coated liposomes (CCLs). FCCLs were spherical in shape with a classic core-shell structure. Compared with conventional liposomes, FCCLs had larger size (average diameter: 182.0 nm), higher zeta potential (10.1 mV), prolonged drug release behaviors (55.76 % after 24 h), and better physical stability when stored at 25 C, all similar to the properties of CCLs. With fluorescein as a model drug, fluorescein-loaded liposomes, CCLs, and FCCLs were prepared and their tumor targeting ability was evaluated according to the in vitro cellular uptake of fluorescein loaded nanoparticles by MCF-7 and HUVEC cells. Results demonstrated that FCCLs had a significant higher uptake by folate receptor positive cells (MCF-7) as compared to traditional liposomes and CCLs, which indicated that the FCCLs were promising nano-carriers for tumor-targeted drug delivery.

Original languageEnglish
Pages (from-to)1717-1727
Number of pages11
JournalJournal of Materials Science
Volume48
Issue number4
DOIs
Publication statusPublished - 2013 Feb 1

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Liposomes
Chitosan
Folic Acid
Tumors
Fluorescein
Targeted drug delivery
Zeta potential
Pharmaceutical Preparations
Spectrum analysis

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Yang, K. K., Kong, M., Wei, Y. N., Liu, Y., Cheng, X. J., Li, J., ... Chen, X. G. (2013). Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery. Journal of Materials Science, 48(4), 1717-1727. https://doi.org/10.1007/s10853-012-6930-0

Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery. / Yang, Kui Kun; Kong, Ming; Wei, Ya Nan; Liu, Ya; Cheng, Xiao Jie; Li, Jing; Park, Hyun Jin; Chen, Xi Guang.

In: Journal of Materials Science, Vol. 48, No. 4, 01.02.2013, p. 1717-1727.

Research output: Contribution to journalArticle

Yang, KK, Kong, M, Wei, YN, Liu, Y, Cheng, XJ, Li, J, Park, HJ & Chen, XG 2013, 'Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery', Journal of Materials Science, vol. 48, no. 4, pp. 1717-1727. https://doi.org/10.1007/s10853-012-6930-0
Yang, Kui Kun ; Kong, Ming ; Wei, Ya Nan ; Liu, Ya ; Cheng, Xiao Jie ; Li, Jing ; Park, Hyun Jin ; Chen, Xi Guang. / Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery. In: Journal of Materials Science. 2013 ; Vol. 48, No. 4. pp. 1717-1727.
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