Follow-up study of peripheral blood carcinoembryonic antigen mRNA using reverse transcription-polymerase chain reaction as an early marker of clinical recurrence in patients with curatively resected gastric cancer

Hong Seo Jae, Won Choi Chul, Soo Kim Byung, Won Shin Sang, Hong Kim Yeul, Sun Kim Jae, Woo Lee Sang, Hyun Choi Jae, Tae Park Yung, Jae Mok Young, Suk Kim Chong, Jun Suk Kim

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21 Citations (Scopus)

Abstract

In this study, we evaluated the clinical significance of detecting carcinoembryonic antigen (CEA) mRNA in the peripheral blood samples of patients with gastric cancer. We analyzed the peripheral blood of 46 patients with gastric cancer who had undergone curative resection. The presence of CEA mRNA was serially monitored using a CEA-specific reverse transcription-polymerase chain reaction (RT-PCR) every 2 months. The clinical recurrence rates according to category were as follows: 100% (3 of 3) in the positive conversion, 0% (0 of 18) in the negative conversion, 50% (3 of 6) in the always-positive, and 10.5% (2 of 19) in the always-negative category. The recurrence rate was 66.7% (6 of 9) in the positive group and 5.4% (2 of 37) in the negative group (P ≤0.00022). Multiple logistic regression analysis demonstrated that only group variable had a significant effect on clinical recurrence (P = 0.015). We conclude that RT-PCR analysis of CEA mRNA in the peripheral blood seems to be a promising tool for the early detection of micrometastatic circulating tumor cells in gastric carcinoma patients and that it can be useful used to identify patients at risk for recurring.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume28
Issue number1
DOIs
Publication statusPublished - 2005 Feb

Keywords

  • CEA
  • Gastric carcinoma
  • Peripheral blood
  • RT-PCR

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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