Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior

Y. R. Yang, J. H. Jung, S. J. Kim, K. Hamada, A. Suzuki, H. J. Kim, J. H. Lee, O. B. Kwon, Y. K. Lee, J. Kim, E. K. Kim, H. J. Jang, D. S. Kang, J. S. Choi, Changjoon Lee, J. Marshall, H. Y. Koh, C. J. Kim, H. Seok, S. H. KimJ. H. Choi, Y. B. Choi, L. Cocco, S. H. Ryu, J. H. Kim, P. G. Suh

Research output: Contribution to journalArticle

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Abstract

Manic episodes are one of the major diagnostic symptoms in a spectrum of neuropsychiatric disorders that include schizophrenia, obsessive-compulsive disorder and bipolar disorder (BD). Despite a possible association between BD and the gene encoding phospholipase Cγ1 (PLCG1), its etiological basis remains unclear. Here, we report that mice lacking phospholipase Cγ1 (PLCγ1) in the forebrain (Plcg1f/f; CaMKII) exhibit hyperactivity, decreased anxiety-like behavior, reduced depressive-related behavior, hyperhedonia, hyperphagia, impaired learning and memory and exaggerated startle responses. Inhibitory transmission in hippocampal pyramidal neurons and striatal dopamine receptor D1-expressing neurons of Plcg1-deficient mice was significantly reduced. The decrease in inhibitory transmission is likely due to a reduced number of γ-aminobutyric acid (GABA)-ergic boutons, which may result from impaired localization and/or stabilization of postsynaptic CaMKII (Ca2+/calmodulin-dependent protein kinase II) at inhibitory synapses. Moreover, mutant mice display impaired brain-derived neurotrophic factor-tropomyosin receptor kinase B-dependent synaptic plasticity in the hippocampus, which could account for deficits of spatial memory. Lithium and valproate, the drugs presently used to treat mania associated with BD, rescued the hyperactive phenotypes of Plcg1f/f; CaMKII mice. These findings provide evidence that PLCγ1 is critical for synaptic function and plasticity and that the loss of PLCγ1 from the forebrain results in manic-like behavior.

Original languageEnglish
Pages (from-to)1473-1482
Number of pages10
JournalMolecular Psychiatry
Volume22
Issue number10
DOIs
Publication statusPublished - 2017 Jan 31
Externally publishedYes

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Prosencephalon
Bipolar Disorder
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Neuronal Plasticity
Startle Reflex
trkB Receptor
Aminobutyrates
Corpus Striatum
Dopamine D1 Receptors
Hyperphagia
Pyramidal Cells
Obsessive-Compulsive Disorder
Valproic Acid
Lithium
Synapses
gamma-Aminobutyric Acid
Hippocampus
Schizophrenia
Anxiety
Learning

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Yang, Y. R., Jung, J. H., Kim, S. J., Hamada, K., Suzuki, A., Kim, H. J., ... Suh, P. G. (2017). Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. Molecular Psychiatry, 22(10), 1473-1482. https://doi.org/10.1038/mp.2016.261

Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. / Yang, Y. R.; Jung, J. H.; Kim, S. J.; Hamada, K.; Suzuki, A.; Kim, H. J.; Lee, J. H.; Kwon, O. B.; Lee, Y. K.; Kim, J.; Kim, E. K.; Jang, H. J.; Kang, D. S.; Choi, J. S.; Lee, Changjoon; Marshall, J.; Koh, H. Y.; Kim, C. J.; Seok, H.; Kim, S. H.; Choi, J. H.; Choi, Y. B.; Cocco, L.; Ryu, S. H.; Kim, J. H.; Suh, P. G.

In: Molecular Psychiatry, Vol. 22, No. 10, 31.01.2017, p. 1473-1482.

Research output: Contribution to journalArticle

Yang, YR, Jung, JH, Kim, SJ, Hamada, K, Suzuki, A, Kim, HJ, Lee, JH, Kwon, OB, Lee, YK, Kim, J, Kim, EK, Jang, HJ, Kang, DS, Choi, JS, Lee, C, Marshall, J, Koh, HY, Kim, CJ, Seok, H, Kim, SH, Choi, JH, Choi, YB, Cocco, L, Ryu, SH, Kim, JH & Suh, PG 2017, 'Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior', Molecular Psychiatry, vol. 22, no. 10, pp. 1473-1482. https://doi.org/10.1038/mp.2016.261
Yang YR, Jung JH, Kim SJ, Hamada K, Suzuki A, Kim HJ et al. Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. Molecular Psychiatry. 2017 Jan 31;22(10):1473-1482. https://doi.org/10.1038/mp.2016.261
Yang, Y. R. ; Jung, J. H. ; Kim, S. J. ; Hamada, K. ; Suzuki, A. ; Kim, H. J. ; Lee, J. H. ; Kwon, O. B. ; Lee, Y. K. ; Kim, J. ; Kim, E. K. ; Jang, H. J. ; Kang, D. S. ; Choi, J. S. ; Lee, Changjoon ; Marshall, J. ; Koh, H. Y. ; Kim, C. J. ; Seok, H. ; Kim, S. H. ; Choi, J. H. ; Choi, Y. B. ; Cocco, L. ; Ryu, S. H. ; Kim, J. H. ; Suh, P. G. / Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. In: Molecular Psychiatry. 2017 ; Vol. 22, No. 10. pp. 1473-1482.
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