Formation of a hairpin structure by telomere 3′ overhang

Kihang Choi, Byong Seok Choi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The telomeres of most eukaryotes contain tandemly-repeated DNA sequences, with a cluster of G residues on one strand. Recent studies showed that the Oxytricha telomeric DNA oligonucleotide, d(G4T4G4), dimerizes to form a quadruplex in the presence of Na+ or K+. We have observed that the oligonucleotide d(G4T4G4) does not dimerize in the presence of Li+ ion at low sample concentrations. In the monomeric state, this molecule forms a simple foldback hairpin structure containing G · G reverse Hoogsteen basepairs in the stem region. This hairpin structure has a thermal stability which is well reconciled with telomere functions in vivo.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalBBA - Gene Structure and Expression
Volume1217
Issue number3
Publication statusPublished - 1994 Apr 6
Externally publishedYes

Keywords

  • Hairpin structure
  • Hoogsteen basepair
  • Telomere

ASJC Scopus subject areas

  • Structural Biology
  • Genetics
  • Biophysics
  • Biochemistry

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