Formation of cellular close-ended tunneling nanotubes through mechanical deformation

Minhyeok Chang, O. Chul Lee, Gayun Bu, Jaeho Oh, Na Oh Yunn, Sung Ho Ryu, Hyung Bae Kwon, Anatoly B. Kolomeisky, Sang Hee Shim, Junsang Doh, Jae Hyung Jeon, Jong Bong Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Membrane nanotubes or tunneling nanotubes (TNTs) that connect cells have been recognized as a previously unidentified pathway for intercellular transport between distant cells. However, it is unknown how this delicate structure, which extends over tens of micrometers and remains robust for hours, is formed. Here, we found that a TNT develops from a double filopodial bridge (DFB) created by the physical contact of two filopodia through helical deformation of the DFB. The transition of a DFB to a close-ended TNT is most likely triggered by disruption of the adhesion of two filopodia by mechanical energy accumulated in a twisted DFB when one of the DFB ends is firmly attached through intercellular cadherin-cadherin interactions. These studies pinpoint the mechanistic questions about TNTs and elucidate a formation mechanism.

Original languageEnglish
Article number3995
JournalScience Advances
Volume8
Issue number13
DOIs
Publication statusPublished - 2022 Apr

ASJC Scopus subject areas

  • General

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