Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system

Keun Sang Oh; Kyung Eun Lee; Sung Sik Han; Sun Hang Cho; Dongmin Kim; Soon Hong Yuk

doi:10.1021/bm049234r

Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system

Keun Sang Oh, Kyung Eun Lee, Sung Sik Han, Sun Hang Cho, Dongmin Kim, Soon Hong Yuk

* Honorary professors

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.

Original language	English
Pages (from-to)	1062-1067
Number of pages	6
Journal	Biomacromolecules
Volume	6
Issue number	2
DOIs	https://doi.org/10.1021/bm049234r
Publication status	Published - 2005 Mar

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1021/bm049234r

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abstract = "A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.",

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AU - Oh, Keun Sang

AU - Lee, Kyung Eun

AU - Han, Sung Sik

AU - Cho, Sun Hang

AU - Kim, Dongmin

AU - Yuk, Soon Hong

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Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system

Abstract

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