Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system

Keun Sang Oh; Kyung Eun Lee; Sung Sik Han; Sun Hang Cho; Dongmin Kim; Soon Hong Yuk

doi:10.1021/bm049234r

Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system

Keun Sang Oh, Kyung Eun Lee, Sung Sik Han, Sun Hang Cho, Dongmin Kim, Soon Hong Yuk

Division of Life Sciences

Research output: Contribution to journal › Article

68 Citations (Scopus)

Abstract

A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.

Original language	English
Pages (from-to)	1062-1067
Number of pages	6
Journal	Biomacromolecules
Volume	6
Issue number	2
DOIs	https://doi.org/10.1021/bm049234r
Publication status	Published - 2005 Mar 1

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ASJC Scopus subject areas

Organic Chemistry
Biochemistry, Genetics and Molecular Biology(all)
Polymers and Plastics
Materials Chemistry

Cite this

Oh, K. S., Lee, K. E., Han, S. S., Cho, S. H., Kim, D., & Yuk, S. H. (2005). Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system. Biomacromolecules, 6(2), 1062-1067. https://doi.org/10.1021/bm049234r

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10.1021/bm049234r