Formation of size-controlled nano carrier systems by self-assembly

S. H. Bang, Y. M. Yu, I. C. Hwang, Hyun Jin Park

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Nano carrier systems were prepared by forming self-assembled liposomes having a size distribution in the nano range through use of an ultrasonic homogenizer. Phosphatidylcholine and cholesterol were utilized as an amphiphilic compound and a shape stabilizer, respectively. The size of prepared samples was decreased (up to 150 nm) by elevating ratio of lecithin and extending homogenization time (2 ∼ 6 min). After secondary coating with alginic acid (0.1, 0.3 and 0.5, W/V), size was remarkably changed in the range of ±30 nm and zeta-potential was altered (only chitosan coating (molecular weight: 30 000 Da, 0.2, W/V): 10.3 mV, Alginic acid coating (0.5, W/V) after the chitosan coating: -21.8 mV). The low molecular weight chitosan (0.1, W/V)-coated nano-liposomes had a lower absolute value of zeta-potential than the high molecular weight chitosan (0.1, W/V)-coated nano-liposomes. The encapsulation efficiency was measured by gas chromatography. The efficiency was decreased slightly by elevating chitosan concentration (0.1 ∼ 0.5, W/V).

Original languageEnglish
Pages (from-to)722-733
Number of pages12
JournalJournal of Microencapsulation
Volume26
Issue number8
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Chitosan
wireless communication
Self assembly
self assembly
Liposomes
coatings
Coatings
Molecular Weight
Molecular weight
Alginate
molecular weight
Zeta potential
acids
cholesterol
Lecithin
low molecular weights
gas chromatography
homogenizing
Lecithins
Cholesterol

Keywords

  • Alginic acid
  • Carrier system
  • Chitosan
  • Electronic attraction
  • Nano liposome
  • Phosphatidylcholine (lecithin)

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Bioengineering
  • Organic Chemistry

Cite this

Formation of size-controlled nano carrier systems by self-assembly. / Bang, S. H.; Yu, Y. M.; Hwang, I. C.; Park, Hyun Jin.

In: Journal of Microencapsulation, Vol. 26, No. 8, 01.12.2009, p. 722-733.

Research output: Contribution to journalArticle

Bang, S. H. ; Yu, Y. M. ; Hwang, I. C. ; Park, Hyun Jin. / Formation of size-controlled nano carrier systems by self-assembly. In: Journal of Microencapsulation. 2009 ; Vol. 26, No. 8. pp. 722-733.
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