Formation of size-controlled nano carrier systems by self-assembly

S. H. Bang, Y. M. Yu, I. C. Hwang, Hyun Jin Park

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Nano carrier systems were prepared by forming self-assembled liposomes having a size distribution in the nano range through use of an ultrasonic homogenizer. Phosphatidylcholine and cholesterol were utilized as an amphiphilic compound and a shape stabilizer, respectively. The size of prepared samples was decreased (up to 150 nm) by elevating ratio of lecithin and extending homogenization time (2 ∼ 6 min). After secondary coating with alginic acid (0.1, 0.3 and 0.5, W/V), size was remarkably changed in the range of ±30 nm and zeta-potential was altered (only chitosan coating (molecular weight: 30 000 Da, 0.2, W/V): 10.3 mV, Alginic acid coating (0.5, W/V) after the chitosan coating: -21.8 mV). The low molecular weight chitosan (0.1, W/V)-coated nano-liposomes had a lower absolute value of zeta-potential than the high molecular weight chitosan (0.1, W/V)-coated nano-liposomes. The encapsulation efficiency was measured by gas chromatography. The efficiency was decreased slightly by elevating chitosan concentration (0.1 ∼ 0.5, W/V).

Original languageEnglish
Pages (from-to)722-733
Number of pages12
JournalJournal of Microencapsulation
Volume26
Issue number8
DOIs
Publication statusPublished - 2009 Dec 1

Keywords

  • Alginic acid
  • Carrier system
  • Chitosan
  • Electronic attraction
  • Nano liposome
  • Phosphatidylcholine (lecithin)

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Bioengineering
  • Organic Chemistry

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